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Objective: To develop models to predict opportunities for improvement in trauma care and compare the performance of these models to the currently used audit filters.
Design: Retrospective registry-based study.
Setting: Single-centre, Scandinavian level one equivalent trauma centre.
Participants: 8220 adult trauma patients screened for opportunities for improvement between 2013 and 2022.
Primary And Secondary Outcome Measures: Two machine learning models (logistic regression and XGBoost) and the currently used audit filters were compared. Internal validation by an expanding window approach with annual updates was used for model evaluation. Performance measured by discrimination, calibration, sensitivity and false positive rate of opportunities for improvement prediction.
Results: A total of 8220 patients, with a mean age of 45 years, were analysed; 69% were men with a mean injury severity score of 12. Opportunities for improvement were identified in 496 (6%) patients. Both the logistic regression and XGBoost models were well-calibrated, with intercalibration indices of 0.02 and 0.02, respectively. The models demonstrated higher areas under the receiver operating characteristic curve (AUCs) (logistic regression: 0.71; XGBoost: 0.74). The XGBoost model had a lower false positive rate at a similar sensitivity (false positive rate: 0.63). The audit filters had an AUC of 0.62 and a false positive rate of 0.67.
Conclusions: The logistic regression and XGBoost models outperformed audit filters in predicting opportunities for improvement among adult trauma patients and can potentially be used to improve systems for selecting patients for trauma peer review.
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http://dx.doi.org/10.1136/bmjopen-2025-099624 | DOI Listing |
Front Oncol
August 2025
Department of Pathology, Institute of Clinical Pathology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Despite the generally favorable prognosis of differentiated thyroid carcinoma (DTC) following surgery and radioactive iodine (RAI) therapy, approximately 10% of cases eventually develop resistance to RAI. This condition, known as radioiodine-refractory differentiated thyroid carcinoma (RAIR-DTC), is associated with a poor prognosis, with a 10-year survival rate of only 10% from the time of metastasis detection. The limited availability of safe and effective alternative treatments poses a significant challenge to clinical management.
View Article and Find Full Text PDFAntimicrob Steward Healthc Epidemiol
September 2025
Department of Obstetrics and Gynecology, Division of Maternal/Fetal Medicine, Prisma Health Upstate, Greenville, SC, USA.
Antimicrobial resistance is an urgent public health threat, and despite significant consumption of antimicrobials in pregnancy, there remain opportunities for improvement of their use in the obstetric population. Improvement in antimicrobial utilization can be streamlined by assessing baseline characteristics, utilization of diagnostic testing, awareness of peripartum protocols, and recognition of penicillin allergies. In a single healthcare system including 8 obstetric hospitals, an administrative review identified 199 different regimens used among 8,528 patients based on American College of Obstetrician and Gynecologists (ACOG) guidelines.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Medical Oncology, Kindai University Faculty of Medicine, Osakasayama, Japan.
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with limited treatment options and poor prognosis. Recent advances in cancer genomic analysis enable the identification of actionable gene alterations, opening new opportunities for personalized therapy. Among these, homologous recombination DNA repair (HRR) gene alterations are associated with distinct biological behavior, favorable prognosis, and increased sensitivity to platinum-based chemotherapy.
View Article and Find Full Text PDFCureus
August 2025
Physiology, SGT University, Gurugram, IND.
Introduction Simulation-based training has been a vital part of medical education since Competency-Based Medical Education (CBME) was introduced, and new guidelines since 2023 have expanded to include simulation as a mandatory methodology of teaching. This method enables learners to build and develop both technical and non-technical abilities in a safe and controlled setting, enhancing their preparedness for real-life medical scenarios. Simulation-based training improves skill acquisition and retention and enhances learners' confidence, reduces anxiety, reinforces learning, corrects errors, and promotes reflective practice, in contrast with the traditional method of teaching.
View Article and Find Full Text PDFJ Appl Res Intellect Disabil
September 2025
School of Music, Theatre and Dance, Colorado State University, Fort Collins, Colorado, USA.
Background: Research indicates that music-based interventions can improve quality of life for neurodiverse adults; however, there is limited research on community choirs. The purpose of this practice-based study was to determine feasibility, initial outcomes, and perceptions of benefits/barriers of participation in a community-based choir for neurodiverse adults.
Method: Seven adults aged 25-33 and diagnosed with an intellectual or developmental disability participated in a 15-week community-based choir led by a credentialed music therapist.