Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with limited therapeutic options and poor long-term survival. Hypericum japonicum Thunb. (Tianjihuang), a traditional Chinese medicine exhibits promising anticancer properties. This study aims to elucidate the multi-target mechanisms of Tianjihuang in treating HCC using network pharmacology and molecular docking techniques.
Methods: The active components of Tianjihuang and their targets were retrieved from TCMSP, PubChem, and Swiss Target Prediction databases. HCC-related targets were identified using GeneCard, OMIM, and TTD databases, and overlapping targets were analyzed. Protein-protein interaction (PPI) networks were constructed and analyzed using Cytoscape. Functional enrichment analysis of key targets was performed via GO and KEGG pathways. Kaplan-Meier curves assessed the clinical relevance of core targets, and molecular docking evaluated the binding affinities between Tianjihuang components and key targets.
Results: Tianjihuang contained seven bioactive components targeting 207 genes, with 77 overlapping HCC-related targets. PPI analysis identified key targets, including AKT1, STAT3, EGFR, and ESR1, which play pivotal roles in HCC pathogenesis. GO and KEGG analysis revealed that Tianjihuang's anti-HCC effects involve multiple biological processes and pathways, such as cell proliferation, apoptosis, and PI3K-Akt signaling. Molecular docking results showed high binding affinities of key components, such as quercetin and gallic acid, with core targets supporting their potential therapeutic effects.
Conclusion: This study demonstrates that Tianjihuang exerts its anti-HCC effects through a multi-component, multi-target, and multi-pathway mechanism. These findings provide a scientific foundation for the clinical application of Tianjihuang and highlight its potential as a complementary therapy for HCC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144007 | PMC |
| http://dx.doi.org/10.1007/s12672-025-02633-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Discovery of Highly Efficient Novel Potential Succinate Dehydrogenase Inhibitors Containing a Stilbene Group for Management of Sheath Blight of Rice and Sclerotinia Stem Rot of Oilseed Rape.
J Agric Food Chem
September 2025
College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
In the search for novel succinate dehydrogenase inhibitors (SDHIs) fungicides for managing rice sheath blight (RSB) and sclerotinia stem rot (SSR), 28 pyrazole-4-carboxamides incorporating stilbene or diphenylacetylene scaffolds were synthesized and evaluated for antifungal activities. The results showed that compound exhibited the most promising antifungal efficacy against and with EC (half maximal effective concentration) values of 0.004 and 0.
View Article and Find Full Text PDFInvestigating the Potential of Curcumin in the Treatment of Nonsmall Cell Lung Cancer: A Systematic Review With Meta-Analysis, Network Pharmacology, and Mendelian Randomization.
Phytother Res
September 2025
Department of Pharmacy, Shanghai General Hospital Jiuquan Hospital (The People's Hospital of Jiuquan), Jiuquan, China.
To evaluate the efficacy and explore the potential mechanism of curcumin for the treatment and prevention of NSCLC. We searched six databases thoroughly for articles published before December 2024. Stata 15.
View Article and Find Full Text PDFAnalysis of the toxicity and mechanisms of osteoporosis caused by cigarette toxicants using network toxicology and molecular docking techniques.
Sci Total Environ
September 2025
Department of Orthopedics and Traumatology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan Province, China. Electronic address:
The objective of this research was to use a network toxicology approach to examine the possible toxicity of the cigarette toxicants nicotine and coal tar that cause osteoporosis (OP) as well as its molecular processes. We determined the primary chemical structures and 128 targets of action of tar and nicotine using the Swiss Target Prediction, NP-MRD, and PubChem databases. We discovered that genes including DNAJB1, CCDC8, LINC00888, ATP6V1G1, MPV17L2, PPCS, and TACC1 had a disease prognostic guiding value by LASSO analysis and differential analysis of GEO microarray data.
View Article and Find Full Text PDFGreen approach to the synthesis of 3,4-dihydropyrimidinone with zirconyl oxychloride as catalyst: In vitro antidiabetic evaluation, molecular dynamic simulation, density functional theory and toxicity assessment.
Bioorg Chem
September 2025
Post Graduate and Research Department of Botany, A.V.V.M. Sri Pushpam College (Affiliated to Bharathidasan University), Poondi 613 503, Thanjavur, India. Electronic address:
The research employed zirconyl oxychloride as a catalyst in a reaction involving pyrazole aldehyde, (thio)urea, and acetyl acetone to establish an aqueous approach for synthesizing 3,4-dihydropyrimidinone derivatives (compounds 4a-j) with potential claims as antidiabetic agents. FT-IR, HR-MS, H NMR and C NMR were employed to analyze the synthesized compounds. The HOMO-LUMO analysis was performed to evaluate the stability of the synthesized derivatives.
View Article and Find Full Text PDFPTTG1 as a common promising target for PCOS, Ovarian Cancer, and Major Depressive Disorder patients.
Comput Biol Chem
September 2025
Department of Bioengineering and Biotechnology, Birla Institute of Technology, Mesra, Ranchi, India. Electronic address:
Women are susceptible to hormonal imbalances and endocrine-related disorders such as Polycystic Ovary Syndrome (PCOS), Ovarian Cancer (OC), and Major Depressive Disorder (MDD). This study aims to identify gene-level interconnections among these conditions using omics-based bioinformatic approaches. Publicly available GEO datasets, viz.
View Article and Find Full Text PDF