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| http://dx.doi.org/10.1016/j.ejim.2025.05.033 | DOI Listing |
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Multifaceted safety concerns of glibenclamide in managing type 2 diabetes: Evidence from real-world adverse event analysis.
Eur J Pharmacol
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Center of Health Administration and Development Studies, Hubei University of Medicine, Shiyan, Hubei, 442000, China. Electronic address:
Background: Glibenclamide (Gli), a second-generation sulfonylurea, has been widely used for managing type 2 diabetes mellitus (T2DM) due to its potent glucose-lowering effect and affordability. Recently, renewed scientific interest has emerged due to its potential anti-aging effects, mediated through mitochondrial function modulation and epigenetic regulation. Despite its longstanding clinical use, Gli's comprehensive real-world safety profile remains incompletely understood.
View Article and Find Full Text PDFRetrospective Evaluation of the Impact of a Multidisciplinary One-Year Online Lifestyle Intervention on Type 2 Diabetes Remission in Nonobese Indian Patients.
J Diabetes Res
August 2025
Department of Medicine, Dia Care-Diabetes Hormone Clinic, Ahmedabad, Gujarat, India.
Despite the high prevalence of T2D among nonobese Indians, there is a notable lack of comprehensive lifestyle intervention studies that target this population. This retrospective study was aimed at filling this gap by evaluating the impact of a multidisciplinary 1-year online intensive lifestyle intervention (ILI) on T2D remission in nonobese Indian patients. Retrospective data from medical records of 1453 nonobese patients (BMI 18.
View Article and Find Full Text PDFUnderstanding the risk of diabetic retinopathy from glucagon-like peptide-1 receptor agonists: a Mendelian randomization study and systematic review of European populations.
Diabetol Metab Syndr
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Department of Pharmacy, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China.
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RA) are extensively prescribed to treat obesity and diabetes. However, previous studies have debated whether GLP-1RA use induces diabetic retinopathy (DR) in diabetic populations, and the relationship between the two is unclear.
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Trends and patterns in antidiabetic medication prescriptions: Insights from Greece's electronic prescription database.
Prim Care Diabetes
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Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Aims: This study aimed to analyze the patterns and trends of antidiabetic medication prescriptions in Greece using data from the National Electronic Prescription Database.
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Insulin icodec (icodec) is a first-in-class once-weekly basal insulin approved for the treatment of adults with type 1 diabetes (T1D) and type 2 diabetes (T2D). Healthcare professionals (HCPs) may benefit from clear and practical guidance on translating the use of icodec from a controlled clinical trial setting into real-world clinical practice to ensure its appropriate implementation. Here, we primarily review the available evidence for icodec in T2D to provide evidence-based clinical recommendations and expert opinions to guide the use of icodec in a clinical setting.
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