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http://dx.doi.org/10.1016/j.jacep.2025.04.003 | DOI Listing |
Circulation
September 2025
Cardiology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Italy (M.P.M).
Cardiac adipose tissue is normally present in the epicardium, but a variable amount can also be present in the myocardium, particularly in the subepicardial regions of the right ventricular anterolateral and apical regions. Pathological adipose tissue changes may occur in both ischemic (previous myocardial infarction) and nonischemic (previous myocarditis, arrhythmogenic cardiomyopathy, lipomatous hypertrophy of the interatrial septum, cardiac lipomas and liposarcomas) conditions, with or without extensive replacement-type myocardial fibrosis. Cardiac magnetic resonance is the gold standard imaging technique to characterize myocardial tissue changes and to distinguish between physiological and pathological cardiac fat deposits.
View Article and Find Full Text PDFEchocardiography
September 2025
Department of Emergency Radiology, Careggi University Hospital, Florence, Italy.
Mitral annular disjunction (MAD) is a structural abnormality characterized by the separation of the mitral valve annulus from the left ventricular myocardium, often in association with mitral valve prolapse (MVP). Initially identified in the 1980s, MAD was not considered clinically significant at the time. However, recent advancements in imaging techniques have renewed interest in its potential role in mitral valve dysfunction and arrhythmias.
View Article and Find Full Text PDFBackground: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disease with a poor prognosis and no curative therapy. It may present as arrhythmogenic sudden cardiac death and inevitably progress to terminal heart failure due to the loss of contractile tissue. This study aimed to generate knock-in (KI) mice carrying the 2 genetic variants (DSG2 p.
View Article and Find Full Text PDFBiomedicines
August 2025
Humanitas Gavazzeni, Via Mauro Gavazzeni, 21, 24125 Bergamo, BG, Italy.
The widespread use of cardiac magnetic resonance imaging (MRI) in clinical practice has enabled the identification of numerous patients with evident damage from previous myocarditis, whether known or unknown. For years, myocardial fibrosis has been a topic of interest due to its established correlation with arrhythmic events in various clinical settings, including ischemic heart disease, dilated cardiomyopathy, and hypertrophic cardiomyopathy. MIBG scintigraphy is a method widely used in patients who are candidates for defibrillator implantation or have experienced heart failure.
View Article and Find Full Text PDFRadiology
August 2025
Laboratoire d'Imagerie Biomédicale, Sorbonne Université, CNRS, INSERM, 15 rue de l'École de Médecine, 75006 Paris, France.
Arrhythmogenic cardiomyopathy (ACM) is a rare inherited disease characterized by fibrofatty replacement of the myocardium, associated with lethal arrhythmias and heart failure. ACM diagnosis is challenging, as it involves clinical, genetic, and multiparametric imaging assessments. Imaging plays a central role in evaluating ACM by targeting the intertwined morphofunctional and tissue abnormalities.
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