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http://dx.doi.org/10.1620/tjem.2025.J066 | DOI Listing |
J Refract Surg
September 2025
From the Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Purpose: To determine the accuracy of a new machine learning-based open-source IOL formula (PEARLS-DGS) in 100 patients who underwent uncomplicated cataract surgery and had a history of laser refractive surgery for myopic defects.
Methods: The setting for this retrospective study was HUMANITAS Research Hospital, Milan, Italy. Data from 100 patients with a history of photorefractive keratectomy or laser in situ keratomileusis were retrospectively analyzed to assess the accuracy of the formula.
Front Pediatr
August 2025
Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
Background: The m.3243A>G mutation in the MT-TL1 gene is the most common mtDNA mutation. The mutation can lead to a spectrum of conditions, including diabetes, hearing loss, heart and muscle involvement, encephalopathy and epilepsy, gastrointestinal problems, and vision impairment, often occurring concurrently-collectively referred to as MELAS (mitochondrial encephalopathy lactic acidosis and stroke-like episodes) syndrome.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
September 2025
Department of Ophthalmology, The People's Hospital of Baoan Shenzhen, Shenzhen 518000, China; Department of Ophthalmology, The Second Affiliated Hospital of Shenzhen University, Shenzhen 518000, China. Electronic address:
Objectives: To investigate the relationship between variability of preoperative ocular biometric measurements and the accuracy of intraocular lens (IOL) power calculation.
Methods: This retrospective study included cataract patients who underwent surgery at the People's Hospital of Baoan Shenzhen from January 2022 to December 2024. Preoperative ocular biometric parameters were measured using the Lenstar LS-900, and the coefficients of variation (CV) of corneal curvature (K1-CV, K2-CV), axial length (AL-CV), anterior chamber depth (ACD-CV) were calculated.
Exp Eye Res
September 2025
Department of Ophthalmology, The Second Affiliated Hospital of Nantong University and First People's Hospital of Nantong City, Nantong, Jiangsu, China; Department of Ophthalmology, Southeast University Affiliated Nantong First People's Hospital, Nantong, Jiangsu, China. Electronic address: wangboai2
This study investigates whether circular RNAs (circRNAs) modulate ferroptosis in lens epithelial cells (LECs) during age-related cataract (ARC) pathogenesis via novel encoded proteins. Initial circRNA-sequencing identified hsa_circ_0068626 (circTFRC) as significantly upregulated in ARC, predominantly localized to the cytoplasm through nuclear-cytoplasmic fractionation and fluorescence in situ hybridization (FISH). Functional assays revealed that circTFRC depletion impaired LECs proliferation and viability, while overexpression exacerbated ferroptosis, evidenced by elevated intracellular reactive oxygen species (ROS) and Fe level via fluorescence probes and flow cytometry.
View Article and Find Full Text PDFInt J Comput Assist Radiol Surg
September 2025
School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, China.
Objective: Cataract surgery is among the most frequently performed procedures worldwide. Accurate, real-time segmentation of the cornea and surgical instruments is vital for intraoperative guidance and surgical education. However, most existing deep learning-based segmentation methods depend on pixel-level annotations, which are time-consuming and limit practical deployment.
View Article and Find Full Text PDF