Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1515/dx-2025-0068DOI Listing

Publication Analysis

Top Keywords

clinical implications
4
implications conjugated
4
conjugated direct
4
direct bilirubin
4
bilirubin testing
4
testing analytical
4
analytical limits
4
limits clinical
4
clinical consequences
4
clinical
2

Similar Publications

Aim Of The Study: To present a case series of four pediatric patients with PDPV, each with a different clinical presentation and surgical management.

Methods: We retrospectively reviewed four cases of PDPV managed at our institution. Two cases were associated with extrahepatic biliary atresia (EHBA) and discovered incidentally during surgery.

View Article and Find Full Text PDF

Purpose: To clinically validate the nursing diagnosis "Inadequate Nutritional Intake" based on elements identified within a specific situation theory framework in the context of children with cancer.

Methods: This is a diagnostic accuracy study following the Standards for Reporting Diagnostic Accuracy Studies (STARD) protocol. Specifically, it refers to the clinical validation phase of the nursing diagnosis Inadequate nutritional intake, using a cross-sectional design.

View Article and Find Full Text PDF

Background: The cluster of differentiation 47 (CD47)-signal regulatory protein alpha (SIRPα) axis is a key regulator of innate immune surveillance, facilitating the neoplastic evasion of macrophage-mediated phagocytosis. Although this pathway has been implicated in tumor immune escape in multiple malignancies, its clinical and prognostic significance in esophageal squamous cell carcinoma (ESCC) remain to be fully elucidated.

Methods: We retrospectively analyzed 100 patients who underwent esophagectomy for resectable ESCC.

View Article and Find Full Text PDF

Transcriptional condensates enrich phosphorylated PRMT2 to stimulate H3R8me2a deposition and hypoxic response in glioblastoma.

Sci China Life Sci

September 2025

State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University Cancer Institute and Hospital, Tianjin Key Labora

Histone arginine methylation by protein arginine methyltransferases (PRMTs) is crucial for transcriptional regulation and is implicated in cancers. Despite their therapeutic potential, some PRMTs present challenges as drug targets due to their context-dependent activities. Here, we demonstrate that hypoxia triggers the rapid condensation of PRMT2, which is essential for its histone H3R8 asymmetric dimethylation (H3R8me2a) activity.

View Article and Find Full Text PDF

Semaphorin 3A-mediated perineuronal nets formation incubates depressive-like behaviors in male mice via activating parvalbumin-expressing interneurons.

Mol Psychiatry

September 2025

Department of Pharmacology, School of Basic Medicine and Department of Pharmacy, Tongji Hospital, Tongji Medical College; and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. chenjg@hu

Dysfunction of parvalbumin-expressing interneurons (PV-INs) in the cerebral cortex has been implicated in major depressive disorder. Perineuronal nets (PNNs), which encapsulate PV-INs, are considered to influence the structural and functional properties of PV-INs. Semaphorin 3A (Sema3A) is a secreted protein constituent of PNNs, but the specific roles of Sema3A in modulating PV-INs during stress remain unknown.

View Article and Find Full Text PDF