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Article Abstract
Objective: This study examines the association between serum D-dimer (D-D), neutrophil-to-lymphocyte ratio (NLR), C-reactive protein to albumin ratio (CRP/ALB), and the prognosis of intravenous thrombolysis in patients with acute ischemic stroke (AIS).
Methods: Ninety AIS patients admitted from June 2021 to October 2023 were included and divided into poor prognosis (29 cases) and good prognosis groups (61 cases) based on 90-day follow-up modified Rankin Scale (mRS) scores. Binary logistic regression identified prognostic factors, while ROC analysis evaluated the predictive efficacy of D-D, NLR, and CRP/ALB. Correlations among these markers were also analyzed.
Results: Binary logistic regression showed that age, D-D, ALB, CRP/ALB, neutrophil count, lymphocyte count, and NLR were significant prognostic risk factors (P < 0.05). ROC analysis yielded AUC values of 0.683 for D-D, 0.769 for NLR, and 0.728 for CRP/ALB, with combined AUC reaching 0.803. Sensitivity and specificity were 96.6%/39.3% for D-D, 100.0%/68.9% for NLR, and 100.0%/45.9% for CRP/ALB. Spearman correlation analysis revealed positive correlations among D-D, NLR, and CRP/ALB (r = 0.367, 0.482, 0.462, p < 0.05).
Conclusion: Age, D-D, ALB, CRP/ALB, neutrophil count, lymphocyte count, and NLR are significant prognostic factors for intravenous thrombolysis in AIS patients. D-D, NLR, and CRP/ALB are effective indicators for predicting prognosis, with combined prediction showing greater efficacy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126098 | PMC |
| http://dx.doi.org/10.2147/IJGM.S516037 | DOI Listing |
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