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Article Abstract
Eight drimane-type sesquiterpenes, including six undescribed ones named spinulactones A-F (-), together with two known labdane-type diterpenoids ( and ) and a sterol (), were isolated from the endophytic fungus 9-1. The structures and absolute configurations of the new compounds were characterized by extensive spectroscopic data, X-ray diffraction analysis, and electronic circular dichroism calculations. Compounds - feature a rare spiro β-lactone moiety, with and additionally incorporating a distinctive nicotinic acid structural motif. Biological evaluation revealed that compounds , , , , and exhibited antifungal activity against the phytopathogen with MIC values ranging from 6.25 to 25 μg/mL. Additionally, compounds , , , and demonstrated significant proangiogenic activity in transgenic zebrafish. Compound also displayed obvious antigastric aging effect . This study expanded the structural diversity of drimane-type sesquiterpenes and provided potential leads for agricultural and pharmaceutical applications.
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