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Background: We aimed to understand and evaluate the types, experiences and levels of engagement of all groups engaged in the OPTimise research study. The OPTimise study used virtual community engagement to engage equity-deserving populations across three sites to help public health units tailor strategies to improve vaccine uptake during COVID-19. Our evaluation was uniquely conducted at arm's length from the OPTimise researchers who facilitated the virtual engagement with these groups.
Method: The community members involved in research (community leaders and citizen partners) were invited to complete the 22-item Patient Engagement in Research Scale (PEIRS-22) survey to understand the nature of engagement. Twenty-three participants were invited to complete the survey and 19 (83%) completed the survey. We conducted individual and focus group interviews with members of all four groups (community leaders, citizen partners, public health unit knowledge user and connectors, and methods researchers) to learn about their engagement experiences with the OPTimise study and research team. Thirty-five participants were invited to join an interview or focus group interview with 22 (63%) completing an interview.
Results: OPTimise study members reported "extremely meaningful" engagement which is the highest level on the PEIRS-22 scale. The interviews demonstrated that the OPTimise study was designed appropriately across the three sites. Interviews were analyzed based on four topics: relationship management, supporting processes, power sharing, and satisfaction with operations. Qualitative and quantitative data are compared to the Levels of Patient and Researcher Engagement in Health Research framework. Citizen partners and methods researchers reported being engaged at the level of "lead" on the framework. Community leaders reported their level of engagement as at the level of "involve" throughout the study while connectors and public health knowledge users reported their level of engagement was at the level of "involve episodically" throughout the study.
Conclusions: This evaluation found that building authentic relationships between the OPTimise research team and participants was key in the early phases of the OPTimise study. Researchers on future projects could benefit from developing working relationships with organizations who can connect with the target audience to facilitate trust building between researchers and engagement participants, especially in virtual environments.
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http://dx.doi.org/10.1186/s12889-025-23149-6 | DOI Listing |
Commun Med (Lond)
September 2025
Department of Microbiology and Immunology, Bio21 Institute and The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Background: Mixed-species, mixed-strain plasmodia infections are known to occur in humans in malaria endemic areas. It may be surprising that to date, the extent of this complexity has not been systematically explored in high-burden countries of sub-Saharan Africa, especially in the reservoir of asymptomatic infections in all ages, which sustains transmission.
Methods: Here we take a metagenomic lens to these infections by sampling variable blood volumes from 188 afebrile residents living in high, seasonal transmission in Northern Sahelian Ghana.
Br J Sports Med
September 2025
Oslo Sports Trauma Research Center, Norwegian School of Sports Sciences, Oslo, Norway.
Objective: To describe the proposed biomedical effect mechanisms in research on exercise-based injury prevention programmes in football (soccer) and handball.
Design: Scoping review of randomised controlled trials (RCT), cohort studies and case studies.
Data Sources: MEDLINE via PubMed, SPORTDiscus and Web of Science databases were searched from 2000 to 2024.
BMJ Open
September 2025
Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Introduction: Nipah virus (NiV) is a bat-transmitted paramyxovirus causing recurrent, high-mortality outbreaks in South and South-East Asia. As a WHO priority pathogen, efforts are underway to develop therapies like monoclonal antibodies and small-molecule antivirals, which require evaluation in clinical trials. However, trial design is challenging due to limited understanding of NiV's clinical characteristics.
View Article and Find Full Text PDFBMJ Open
September 2025
Department of Nursing, Mettu University, Mettu, Oromia, Ethiopia.
Background: Antenatal care (ANC) is a critical component for improving maternal and newborn health. It provides a platform for essential healthcare services, including health promotion, screening and diagnosis, injury and disease prevention, birth preparedness and preparation for the postnatal period. By implementing timely and appropriate evidence-based practices, ANC can reduce maternal and child morbidity and mortality and optimise overall health and well-being.
View Article and Find Full Text PDFBMJ Open
September 2025
Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, UK.
Introduction: Relational continuity of care (RCC) refers to the sustained therapeutic relationship between a patient and a clinician, which fosters trust, enhances communication and facilitates the accumulation of knowledge about the patient. RCC is associated with enhanced patient outcomes, reduced hospital admissions, lower mortality rates, decreased healthcare costs and improved patient experience. Despite these benefits, reorganisations within the NHS and workforce challenges have led to an increased reliance on multidisciplinary and part-time working, resulting in fragmented care and a decline in RCC.
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