Building Capacity for Knowledge Translation in Rehabilitation: The Academy of Neurologic Physical Therapy's Knowledge Translation Summit.

Background And Purpose: Enhancing health care through the implementation of evidence-based practices is a complex task, demanding specialized expertise and a distinct set of skills to facilitate success. A knowledge translation (KT) capacity-building initiative is a process that leads to greater individual, organizational, or system capabilities to translate high-quality evidence, such as clinical practice guidelines, into practice. The KT Summit, a KT capacity-building initiative, was developed by the Academy of Neurologic Physical Therapy and includes an in-person workshop, quarterly reports, mentoring for 2 years, and a funding opportunity.

Clinician underprescription of and patient nonadherence to clinical practice guideline-recommended medications for peripheral artery disease: a systematic review and meta-analysis.

Background: Guidelines recommend that adults with peripheral artery disease (PAD) take antiplatelets, statins, and antihypertensives. However, it is unclear how frequently clinicians do not prescribe these medications (ie, underprescription), how often patients fail to fill/refill their prescriptions (ie, nonadherence), which factors increase underprescription/nonadherence risk, and whether underprescription/nonadherence are associated with outcomes.

Methods: We searched MEDLINE, EMBASE, CENTRAL, and Evidence-Based Medicine Reviews (January 1, 2006-to-February 18th, 2025) for studies reporting cumulative incidences/point prevalences of clinician underprescription and/or patient nonadherence to antiplatelets, statins, and/or antihypertensives; adjusted-risk factors for underprescription/nonadherence; and adjusted-outcomes associated with underprescription/nonadherence among adults with PAD.

How does integrated knowledge translation work? A realist review.

Background: Integrated knowledge translation (IKT), or research co-production, is a research approach where researchers and knowledge users carry out a study as equal partners. A growing evidence base demonstrates that IKT produces research findings that are useful, usable and used. Despite knowing how IKT works, we have yet to ascertain how it operates.

It is time to acknowledge and act on the importance of power in integrated knowledge translation.

Integrated knowledge translation (IKT) has emerged as an approach to research centered on collaboration between researchers and knowledge users, particularly in health research. There has been a growing focus on power within the IKT literature, especially the concern that overlooking power inequities within IKT partnerships may reproduce forms of knowledge production and dissemination that do not align with IKT's aspirations of shared decision making to produce useful and usable research findings. However, there remain significant gaps in our understanding of how to address and attend to power in IKT.

A Crossover Trial of Hospital-Wide Lactated Ringer's Solution versus Normal Saline.

Background: Whether lactated Ringer's solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain.

Methods: In an open-label, two-period, two-sequence, cross-sectional, cluster-randomized, crossover trial, we assigned hospitals in Ontario, Canada, to use either lactated Ringer's solution or normal saline hospital-wide for a period of 12 weeks. After a washout period, hospitals switched to the other fluid for 12 weeks.

A multi-method evaluation of how equity deserving communities were engaged in research.

Background: We aimed to understand and evaluate the types, experiences and levels of engagement of all groups engaged in the OPTimise research study. The OPTimise study used virtual community engagement to engage equity-deserving populations across three sites to help public health units tailor strategies to improve vaccine uptake during COVID-19. Our evaluation was uniquely conducted at arm's length from the OPTimise researchers who facilitated the virtual engagement with these groups.

Effectiveness of patient decision aids for cardiovascular decisions: Systematic review with sex/gender-based analysis.

Aims: Determine effectiveness of cardiovascular patient decision aids (PtDAs), assess consideration for sex and/or gender in included trials, and report whether PtDAs included sex/gender information in personal cardiovascular risk calculations, benefits or harms.

Methods And Results: Systematic review with meta-analysis. Independent reviewers screened 209 trials in the 2024 Cochrane Review of PtDAs for eligible cardiovascular trials with updated search to February 2025.

Study protocol for assessing the effectiveness, implementation fidelity and uptake of attachment & child health (ATTACH™) Online: helping children vulnerable to early adversity.

Background: Exposure to early childhood adversities, such as family violence, parental depression, or low-income, undermine parent-child relationship quality and attachment leading to developmental and mental health problems in children. Addressing impacts of early childhood adversity can promote children's development, giving them the best start in life. Parental reflective function (RF), or parents' ability to understand their own and children's mental states, can strengthen parent-child relationships and attachment and buffer the negative effects of early adversity.

Patient engagement for the development of equity-focused health technology assessment (HTA) recommendations: a case study of two Canadian HTA organizations.

Background: Health technology assessment (HTA) is a form of policy analysis that informs decisions about funding and scaling up health technologies to improve health outcomes. An equity-focused HTA recommendation explicitly addresses the impact of health technologies on individuals disadvantaged in society because of specific health needs or social conditions. However, more evidence is needed on the relationships between patient engagement processes and the development of equity-focused HTA recommendations.

Partnered health research in Canada: a cross-sectional survey of perceptions among researchers and knowledge users involved in funded projects between 2011 and 2019.

Background: Engaging knowledge users in health research is accelerating in Canada. Our objective was to examine perceptions of partnered health research among individuals involved in funded Canadian partnered health research projects between 2011 and 2019.

Methods: We invited 2155 recipients of 1153 funded projects to answer a questionnaire probing project characteristics and perceptions of partnered health research.

Research priority setting for implementation science and practice: a living systematic review protocol.

Background: Research priority setting has the potential to bridge knowledge gaps, optimize resource allocation, foster collaborations, and inform funding directions for implementation science and practice when these priorities are properly acted upon. This systematic review aims to determine the extent of research in priority setting for implementation science and practice, examine the methodologies employed, synthesize these research priorities, and identify strategies for evaluating and implementing these priorities.

Methods: We will conduct a living systematic review following the Cochrane guidance.

Implementing Guidelines for hypothermia prevention with Local adaptation to keep periOperative patients Warm (GLOW): protocol of a stepped-wedge cluster randomised hybrid type II effectiveness-implementation study.

Introduction: Perioperative hypothermia is a common and preventable complication of surgery. Systems level change that enables perioperative teams to integrate hypothermia prevention into practice in ways that are contextually appropriate is needed. The purpose of this trial is to evaluate the effectiveness and implementation of perioperative hypothermia prevention guidance with local adaptation on clinical, implementation and economic outcomes.

Implementation processes and capacity-building needs in Ontario maternal-newborn care hospital settings: a cross-sectional survey.

Background: Maternal-newborn care does not always align with the best available evidence. Applying implementation science to change initiatives can help move evidence-informed practices into clinical settings. However, it remains unknown to what extent current implementation practices in maternal-newborn care align with recommendations from implementation science, and how confident nurses, other health professionals, and leaders are completing steps in the implementation process.

Advancing scaling science in health and social care: a scoping review and appraisal of scaling frameworks.

Background: Scaling is typically discussed as a way to amplify or expand a health innovation. However, there is limited knowledge about the specific techniques that can enhance access to or improve the quality of innovations, aiming to increase their positive impacts for the public good. We sought to identify, compare, and contrast scaling frameworks to advance the science and practice of scaling.

Guidance for engagement in health guideline development: A scoping review.

Background: Health guideline developers engage with interested people and groups to ensure that guidelines and their recommendations are relevant and useful to those who will be affected by them. These 'interest-holders' include patients, payers/purchasers of health services, payers of health research, peer review editors, product makers, programme managers, policymakers, providers, principal investigators, and the public. The Guidelines International Network (GIN) and McMaster University Guideline Development Checklist describes 146 steps of the guideline process organized into 18 topics.

Protocol: Assessing the impact of interest-holder engagement on guideline development: A systematic review.

This is the protocol for a Campbell systematic review. The objectives are as follows. The objective of this review is to identify and synthesize empirical research on the impacts of interest-holder engagement on the guideline development process and content.

Planning for implementation success: insights from conducting an implementation needs assessment.

Aim: The aim of this paper is to provide insights into conducting an implementation needs assessment using a case example in a less-research-intensive setting.

Design And Methods: In the case example, an implementation needs assessment was conducted, including (1) an environmental scan of the organization's website and preliminary discussions with key informants to learn about the implementation context, and (2) a formal analysis of the evidence-practice gap (use of sedation interruptions) deploying a chart audit methodology using legal electronic reports.

Results: Our needs assessment was conducted over 5 months and demonstrated how environmental scans reveal valuable information that can inform the evidence-practice gap analysis.

Research Coproduction: An Underused Pathway to Impact.

Knowledge translation and implementation science have made many advances in the last two decades. However, research is still not making expedient differences to practice, policy, and service delivery. It is time to evolve our approach to knowledge production and implementation.

Interventions that have potential to help older adults living with social frailty: a systematic scoping review.

Background: The impact of social frailty on older adults is profound including mortality risk, functional decline, falls, and disability. However, effective strategies that respond to the needs of socially frail older adults are lacking and few studies have unpacked how social determinants operate or how interventions can be adapted during periods requiring social distancing and isolation such as the COVID-19 pandemic. To address these gaps, we conducted a scoping review using JBI methodology to identify interventions that have the best potential to help socially frail older adults (age ≥65 years).