Publications by authors named "Dewan Imtiaz Rahman"

Objectives: Nipah virus (NiV) causes deadly outbreaks in Bangladesh, with a fatality rate of 71%. Two sublineages, NiV-BD 1 and NiV-BD 2, have been identified. This study aimed to characterize their epidemiologic and clinical diversity.

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Nipah virus (NiV) causes severe diseases in humans with a high case fatality rate. The primary risk factors for NiV infection in Bangladesh are drinking raw date palm sap (DPS) contaminated with Pteropus fruit bat secretions/excretions or close contact with or exposure to the body fluid of an individual with NiV infection. During the 2023 NiV outbreak investigation in Bangladesh, the breast milk of a NiV-infected nursing mother was tested by real-time reverse transcriptase polymerase chain reaction (RT-PCR) for detection of NiV-RNA.

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Article Synopsis
  • * Researchers developed a simple "mix-and-read" biosensor using a split NanoLuc luciferase to detect anti-NiV antibodies in samples, validated with over 700 serum samples from Bangladesh.
  • * The new biosensor showed high sensitivity (98.6%) and specificity (100%) compared to existing tests, though it is less effective for detecting antibodies shortly after symptoms begin, making it a valuable tool for NiV surveillance and outbreak investigations.
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