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Article Abstract
Objective: Patient-level ultrasound joint inflammation outcomes, derived from the European Alliance of Associations for Rheumatology-Outcome Measures in Rheumatology (EULAR-OMERACT) joint-level scoring of elementary components and the combined score (CS), were compared with measures of disease activity and joint damage in patients with rheumatoid arthritis (RA).
Methods: Clinical joint assessment and a 22-joint (bilateral hands/wrists) ultrasonography were performed independently during the same patient study visit. Patient-level ultrasound joint inflammation outcomes [total power Doppler (PD) score, total grayscale (GS) score, total CS, number of joint(s) with CS ≥ 2 (at least moderate synovitis), and number of joint(s) with ultrasound synovitis defined as PD > 0 or GS ≥ 2] derived from the EULAR-OMERACT joint-level scoring system were correlated with Clinical Disease Activity Index (CDAI), 28-joint disease activity score (DAS28), and ultrasound-detected joint damage, i.e., total bone erosion score (TBES). The relationship between the variables was studied using simple linear regression.
Results: A total of 83 RA patients underwent scanning of 1,826 joints in this cross-sectional study. All patient-level ultrasound joint inflammation outcomes showed significant correlations ( < 0.01) with CDAI, DAS28, and TBES (with correlation coefficients ranging from 0.45 to 0.48, 0.38 to 0.45, and 0.66 to 0.83, respectively). A linear regression analysis revealed statistically significant relationships ( < 0.01) for all patient-level ultrasound joint inflammation outcomes in relation to CDAI, DAS28, and TBES (with regression coefficients ranging from 0.603 to 1.260, 0.066 to 0.149, and 0.416 to 0.818, respectively).
Conclusion: Patient-level ultrasound joint inflammation outcomes, derived from the EULAR-OMERACT joint-level scoring system, showed good construct validity when compared to both disease activity and joint damage in patients with RA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119249 | PMC |
| http://dx.doi.org/10.3389/fmed.2025.1564381 | DOI Listing |
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