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This review aimed to analyze the effects of laughter-inducing therapy on anxiety, pain, and stress in children by synthesizing existing randomized controlled trials (RCTs). Researchers conducted a systematic literature review and meta-analysis, following the Cochrane Collaboration's methodology for systematic literature review and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We selected and evaluated 12 studies for quality using the Risk of Bias 2.0 tool. Seven studies were included in the meta-analysis, which showed that clown therapy produced a moderate effect on pain relief and a large effect on anxiety reduction in pediatric patients. In conclusion, this review highlights the potential of laughter-inducing therapies as an effective clinical intervention for reducing anxiety, pain, and stress in pediatric patients. These findings provide evidence supporting the use of laughter-based interventions as alternative or complementary approaches in medical settings. The review also underscores the need for further research across diverse clinical environments to validate the effectiveness of laughter-inducing therapies in broader pediatric populations. Overall, the incorporation of laughter-inducing therapy into clinical practice may play a valuable role in enhancing the overall well-being of pediatric patients.
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http://dx.doi.org/10.1177/13674935251346886 | DOI Listing |
BMC Pediatr
September 2025
Pediatric Surgery Department, Faculty of Medicine, Minia University, Minia, Egypt.
Aim Of The Study: To present a case series of four pediatric patients with PDPV, each with a different clinical presentation and surgical management.
Methods: We retrospectively reviewed four cases of PDPV managed at our institution. Two cases were associated with extrahepatic biliary atresia (EHBA) and discovered incidentally during surgery.
BMC Pediatr
September 2025
Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.
Background: This study aimed to evaluate the impact of asthma severity on biventricular cardiac functions using tissue Doppler imaging (TDI), two-dimensional speckle tracking echocardiography (2D-STE), and three-dimensional speckle tracking echocardiography (3D-STE).
Methods: Sixty-three children with asthma, aged between 5 and 16 years, were enrolled in the study along with 63 matched controls. All participants underwent cardiac assessments, including TDI, 2D-STE, 3D-STE, conventional echocardiography, and pulmonary function testing with spirometry.
Pediatr Nephrol
September 2025
Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Background: Kidney involvement in pediatric sarcoidosis is rare and often underrecognized, leading to diagnostic delays and treatment challenges. We report six patients with renal sarcoidosis to highlight their diverse presentations and outcomes and challenges in management.
Methods: Medical records of patients diagnosed with renal sarcoidosis during 2020-24 were reviewed.
Eur Radiol Exp
September 2025
Center for MR-Research, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Background: Fetal MRI is increasingly used to investigate fetal lung pathologies, and super-resolution (SR) algorithms could be a powerful clinical tool for this assessment. Our goal was to investigate whether SR reconstructions result in an improved agreement in lung volume measurements determined by different raters, also known as inter-rater reliability.
Materials And Methods: In this single-center retrospective study, fetal lung volumes calculated from both SR reconstructions and the original images were analyzed.
Nat Genet
September 2025
Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
Despite advances in genomic diagnostics, the majority of individuals with rare diseases remain without a confirmed genetic diagnosis. The rapid emergence of advanced omics technologies, such as long-read genome sequencing, optical genome mapping and multiomic profiling, has improved diagnostic yield but also substantially increased analytical and interpretational complexity. Addressing this complexity requires systematic multidisciplinary collaboration, as recently demonstrated by targeted diagnostic workshops.
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