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Related studies have revealed that the phonological features of depressed patients are different from those of healthy individuals. With the increasing prevalence of depression, objective and convenient early screening is necessary. To this end, we propose an automatic depression detection method based on hybrid speech features extracted by deep learning, dubbed as TTFNet. Firstly, to effectively excavate the intrinsic relationship among multidimensional dynamic features in the frequency domain, the Mel spectrogram of raw speech and its related derivatives are encoded into quaternion representation. Then, the innovatively designed quaternion VisionLSTM is utilized to capture their synergistic effects. Simultaneously, we integrate sLSTM with the pre-trained wav2vec 2.0 model to fully acquire the temporal features. In addition, to further exploit the complementarity between temporal and frequency features, we design an XConformer block for cross-sequence interactions, which ingeniously combines self-attention mechanisms and convolutional modules. The designed XCFF fusion module, based on the XConformer block, enables multi-level interactions between frequency-domain and temporal-domain, thereby enhancing generalization ability of the proposed model. Extensive experiments conducted on the AVEC 2013, AVEC 2014, DAIC-WOZ and E-DAIC datasets demonstrate that our method outperforms current state-of-the-art methods in both depression recognition and severity prediction tasks.
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http://dx.doi.org/10.1109/JBHI.2025.3574864 | DOI Listing |
IEEE Trans Neural Syst Rehabil Eng
September 2025
Given the significant global health burden caused by depression, numerous studies have utilized artificial intelligence techniques to objectively and automatically detect depression. However, existing research primarily focuses on improving the accuracy of depression recognition while overlooking the explainability of detection models and the evaluation of feature importance. In this paper, we propose a novel framework named Enhanced Domain Adversarial Neural Network (E-DANN) for depression detection.
View Article and Find Full Text PDFCompr Physiol
October 2025
School of Pharmacy and Medical Sciences, Griffith University, Southport, Queensland, Australia.
Mechanisms underlying cardiovascular, affective, and metabolic (CAM) multimorbidity are incompletely defined. We assessed how two risk factors-chronic stress (CS) and a Western diet (WD)-interact to influence cardiovascular function, resilience, adaptability, and allostatic load (AL); explore pathway involvement; and examine relationships with behavioral, metabolic, and systemic AL. Male C57Bl/6 mice (8 weeks old, n = 64) consumed a control (CD) or WD (12%-65%-23% or 32%-57%-11% calories from fat-carbohydrate-protein) for 17 weeks, with half subjected to 2 h daily restraint stress over the final 2 weeks (CD + CS and WD + CS).
View Article and Find Full Text PDFPol J Radiol
July 2025
Department of Neurosurgery, Functional and Stereotactic Neurosurgery, CM UMK Bydgoszcz, Poland.
Diffusion tensor imaging (DTI) and tractography are powerful non-invasive techniques for studying the human brain's white matter pathways. The uncinate fasciculus (UF) is a key frontotemporal tract involved in emotion regulation, memory, and language. Despite advancements, challenges persist in accurately mapping its structure and function due to methodological limitations in data acquisition and analysis.
View Article and Find Full Text PDFEnviron Res
August 2025
College of Life Science, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China. Electronic address:
Chronic psychosocial stress is a major risk factor for major depressive disorder (MDD). The impact of 17β-trenbolone (17-TB), an anabolic steroid and potential environmental endocrine disruptor, on stress responses and mood states in mammals is unclear. In this study, we explored how 17-TB interacts with chronic social defeat stress (CSDS) to drive neuroinflammatory cascades and behavioral abnormalities in mice.
View Article and Find Full Text PDFJ Cancer Surviv
September 2025
Université de Lyon, Université Lyon 1, INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Centre, F-69676, Bron, France.
Purpose: Cancer-related cognitive impairment (CRCI) refers to cognitive changes described by cancer patients. While subjective cognitive difficulties in survivors are well screened by questionnaires, CRCI remains seldom diagnosed by neuropsychological tests. New objective approaches are needed to detect CRCI.
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