Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Arsenic is a known reproductive toxicant to fish; however, the persistence of its toxicity beyond the parental generation remains unclear. The present study investigated the effects of maternal and paternal arsenic exposure via diet on the reproduction and development of zebrafish offspring. Adult male zebrafish exposed to dietary arsenic [30, 60 or 100 μg/g as arsenite for 90 days; F generation] were crossed with unexposed (control) females and vice versa to generate F progeny of maternal (ME) and paternal (PE) arsenic exposures, respectively. F larvae were raised to adulthood in clean water and diet, and males and females from respective ME and PE groups were then bred to evaluate the reproductive and developmental effects of parental arsenic exposure in the offspring generations. A significant reduction in fecundity, fertilization success, and larval (F) development was observed with ME to arsenic, even at the lowest dose. However, similar effects were only recorded with PE to arsenic at medium and high doses. In addition, the HPG axis genes were consistently downregulated in F males and females of both ME and PE treatment groups. The circulating E2 and VTG levels were also decreased in F females of the ME treatment groups, whereas the circulating 11-KT levels were reduced in F males of both the ME and PE treatment groups. In general, dysregulation of the HPG axis was more sensitive to the ME than the PE. In addition, arsenic exposure induced hypermethylation of the promoter region of key HPG axis genes, notably sf-1 in the brain and cyp19a1a in the gonads in both males and females of F and F generations of maternal and paternal arsenic lineages. Overall, our study demonstrated that both maternal and paternal arsenic exposure causes reproductive and developmental toxicity in zebrafish offspring, likely by disrupting the HPG axis via epigenetic alterations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.envpol.2025.126528 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Parental Postpartum Depression and Children's Socioemotional Development: The Role of Socioeconomic Inequality.
JAACAP Open
September 2025
University of Montreal, Montreal, Quebec, Canada.
Objective: Parental postpartum depression (PPD) is a documented risk factor for mental health problems in childhood, but little is known about its interplay with family socioeconomic status (SES). This study tested the interactive effect of SES in the associations of PPD with mental health symptoms in children from infancy to adolescence.
Method: Data used for this study were from the Quebec Longitudinal Study of Child Development.
Gender perception of physician candidates: a cross-sectional study from Turkey.
Korean J Med Educ
September 2025
Department of Family Medicine, Necmettin Erbakan University, Konya, Turkey.
Purpose: This study investigated how socio-cultural characteristics, including gender, age, socioeconomic status, religiosity, and parental education, influence the gender perceptions of medical students and how these perceptions are influenced by medical education.
Methods: This cross-sectional study enrolled 380 volunteer medical students who completed a questionnaire comprising sociodemographic items, the validated Nijmegen Gender Awareness in Medical Scale, and the Perception of Gender Scale (PGS). Statistical significance was set at p<0.
Do purpose in life and self-directedness mediate the effects of child abuse on anxiety and depression symptoms 18 years later?
J Affect Disord
September 2025
National University of Singapore (NUS), Department of Psychology, Singapore. Electronic address:
Background: Childhood maltreatment is a transdiagnostic risk factor that is robustly associated with the development of anxiety and depressive disorder symptoms in adulthood. This study thus aimed to investigate potential mediators between early childhood abuse and adult psychopathology severity using data from an 18-year longitudinal study among community-dwelling adults in the U.S.
View Article and Find Full Text PDFDad's Diet Shapes the Future: How Paternal Nutrition Impacts Placental Development and Childhood Metabolic Health.
Mol Nutr Food Res
September 2025
Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Early-life programming is a major determinant of lifelong metabolic health, yet current preventive strategies focus almost exclusively on maternal factors. Emerging experimental and preclinical data reveal that a father's diet before conception, particularly high-fat intake, also shapes offspring physiology. Here, we synthesize the latest evidence on how such diets remodel the sperm epigenome during two discrete windows of vulnerability: (i) testicular spermatogenesis, via DNA methylation and histone modifications, and (ii) post-testicular epididymal maturation, where small non-coding RNAs are selectively gained.
View Article and Find Full Text PDFSubstance use runs in families. Beyond genetic transmission, parental genetics can indirectly influence offspring substance use through the rearing environment, known as "genetic nurture". This study utilized transmitted and non-transmitted polygenic scores to investigate genetic nurture effects on tobacco, alcohol and cannabis use in up to 15,863 adults with at least one genotyped parent from the Lifelines cohort.
View Article and Find Full Text PDF