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http://dx.doi.org/10.3389/fneur.2025.1609898 | DOI Listing |
Immunotherapy
September 2025
Gustave Roussy Cancer Campus, Villejuif, France.
Essays Biochem
September 2025
Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, 215123, China.
The intricate regulation of the immune system, maintaining equilibrium between pathogen defense and self-tolerance, is fundamental to health. Disruptions in this delicate balance underlie a vast spectrum of human diseases, extending beyond oncology to encompass autoimmune disorders, chronic inflammatory conditions, infectious diseases, allergies, and hypertension. While traditional therapies often rely on broad immunosuppression or direct pathogen eradication, the rapidly evolving field of immunomodulation offers a nuanced alternative: precisely calibrating immune responses to restore homeostasis or achieve targeted defense.
View Article and Find Full Text PDFJ Thorac Oncol
July 2025
Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Introduction: TNM staging systems create prognostic categories by anatomic extent of disease. Whether therapeutically important molecular alterations in NSCLC augment the prognostic information of TNM staging is unclear. To study this, we analyzed molecular data from the ninth edition of the lung cancer staging system.
View Article and Find Full Text PDFFront Vet Sci
August 2025
Immunology Unit, Department of Physiology, Faculty of Veterinary, Universidad de Extremadura, Cáceres, Spain.
Virtual laboratories provide a risk-free environment for students to conduct experiments, particularly those involving hazardous materials or complex procedures. Previous studies have shown that gamified elements and interactive tools enhance the interest of students and promote active participation. In the case of Immunology in the veterinary degree, our prior observations indicate that veterinary students experience learning difficulties with topics related to molecules and effector functions of the immune system.
View Article and Find Full Text PDFFront Vet Sci
August 2025
Laboratorio Avi-Mex, S. A. de C. V., Ciudad de Mexico, Mexico.
Introduction: The emergence of highly virulent strains of the porcine reproductive and respiratory syndrome virus has driven the need for new vaccines. This study evaluates the efficacy of an intranasal (IN) vaccine composed of a naturally attenuated PRRSV-2 isolate, compared to a commercially available intramuscularly administered (IM) PRRSV-1 vaccine, against a heterologous challenge with a highly virulent PRRSV-1 strain (R1).
Methods: Sixty-eight PRRSV-naïve pigs were divided into four groups: two non-vaccinated controls (NV/NCh, NV/Ch), one IM-vaccinated with a PRRSV-1 MLV (Por), and one intranasally (IN)-vaccinated with the PRRSV-2 vaccine (IL).