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Developmental dysplasia of the hip (DDH) is a common orthopaedic condition in infants with an incidence of 1 in 1000 infants. An ultrasound can be performed at 6 weeks if the infant exhibits any risk factors, either intrauterine or at birth. If an ultrasound is positive for DDH, treatment typically begins with a dynamic brace such as the Pavlik harness. If bracing is unsuccessful or the infant presents at an age deemed too late to start brace treatment, closed reduction should be considered. Typically, this is done under anesthesia holding the infant in the so-called human position and maintaining this for at least three months. One of the significant challenges of casting after a closed reduction is maintaining hygiene for the entire 3 months of treatment. This paper presents a detailed surgical technique guide to help physicians with closed reduction, casting with waterproof material, and advanced perioperative imaging to confirm reduction. •Developmental dysplasia of the hip (DDH) is a common orthopaedic condition in infants with an incidence of 1 in 1000 infants.•The standard intervention after Pavlik harness or abduction bracing is closed reduction and casting.•Waterproof casting addresses the significant challenge of maintaining hygiene for the full 3 months of treatment after closed reduction and casting for DDH.•Confirmation of closed reduction can be achieved with arthrogram or advanced imaging such as 3D CT.
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http://dx.doi.org/10.55275/JPOSNA-2023-650 | DOI Listing |
F1000Res
September 2025
School of Management, University of Khartoum, Khartoum, Khartoum, Sudan.
Background: At the 2020 UN General Assembly, China pledged to peak carbon emissions before 2030 and achieve carbon neutrality by 2060. However, the traditional social development model has led to increasing carbon emissions annually, highlighting the need to resolve the contradiction between development and carbon reduction. This study examines the relationship between carbon emissions, economy, population, and energy consumption in a specific region to support carbon peak and neutrality goals.
View Article and Find Full Text PDFContemp Clin Trials
September 2025
Quantitative Sciences Unit, Stanford School of Medicine, United States of America.
Background: Non-collegiate young adults engage in high rates of heavy drinking but are less likely to access alcohol-related counseling or treatment. Peers play a significant role in shaping drinking behavior, yet few interventions target close peer influence in this population.
Methods: This two-arm randomized controlled trial will enroll 300 young adults aged 18-25 who report 2+ heavy drinking days (HDD; defined as 4+ drinks for a woman and 5+ drinks for a man) in the past 30 days and are not enrolled in college.
Fish Shellfish Immunol
September 2025
College of Marine Sciences, State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and
The closely related cytokines Interleukin-4 (IL-4) and IL-13 regulate the Th2 immune response by interacting with their specific receptor complexes. MicroRNAs (miRNAs) modulate various biological pathways through mechanisms that either repress mRNA translation or promote messenger RNA degradation. The miRNA miR-126b is implicated in fish embryonic development.
View Article and Find Full Text PDFEnviron Monit Assess
September 2025
Department of Geosciences, University of Bremen, Bremen, Germany.
Surveillance monitoring of shallow groundwater revealed that redox conditions can vary on a small scale. Therefore, the aim of this study was to categorize redox conditions in the groundwater of Lower Saxony, Germany, and to analyze the spatial distribution and trends of parameters related to redox conditions during surveillance monitoring from 1957 to 2015 in Lower Saxony, Germany. Methodically, trends were considered by applying the Mann-Kendall test and redox conditions of groundwater were classified according to the scheme of Jurgens et al.
View Article and Find Full Text PDFElife
September 2025
Center for Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Human cytomegalovirus (HCMV) infects up to 80% of the world's population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 hr after infection. Integrative analyses reveal HCMV-induced perturbation of Hippo signaling through drastic reduction of TEAD1 transcription factor activity.
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