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Laparoscopic surgery for endometriosis presents unique challenges due to the complexity of and variability in lesion appearances within the abdominal cavity. This study investigates the application of deep learning models for object detection in laparoscopic videos, aiming to assist surgeons in accurately identifying and localizing endometriosis lesions and related anatomical structures. A custom dataset was curated, comprising of 199 video sequences and 205,725 frames. Of these, 17,560 frames were meticulously annotated by medical professionals. The dataset includes object detection annotations for 10 object classes relevant to endometriosis, alongside segmentation masks for some classes. To address the object detection task, we evaluated the performance of two deep learning models-FasterRCNN and YOLOv9-under both stratified and non-stratified training scenarios. The experimental results demonstrated that stratified training significantly reduced the risk of data leakage and improved model generalization. The best-performing FasterRCNN object detection model achieved a high average test precision of 0.9811 ± 0.0084, recall of 0.7083 ± 0.0807, and mAP50 (mean average precision at 50% overlap) of 0.8185 ± 0.0562 across all presented classes. Despite these successes, the study also highlights the challenges posed by the weak annotations and class imbalances in the dataset, which impacted overall model performances. In conclusion, this study provides valuable insights into the application of deep learning for enhancing laparoscopic surgical precision in endometriosis treatment. The findings underscore the importance of robust dataset curation and advanced training strategies in developing reliable AI-assisted tools for surgical interventions. The latter could potentially improve the guidance of surgical interventions and prevent blind spots occurring in difficult to reach abdominal regions. Future work will focus on refining the dataset and exploring more sophisticated model architectures to further improve detection accuracy.
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http://dx.doi.org/10.3390/diagnostics15101254 | DOI Listing |
PLoS One
September 2025
Department of Smart Manufacturing, Industrial Perception and Intelligent Manufacturing Equipment Engineering Research Center of Jiangsu Province, Nanjing Vocational University of Industry Technology, Nanjing, Jiangsu, China.
In the field of quality control, metal surface defect detection is an important yet challenging task. Although YOLO models perform well in most object detection scenarios, metal surface images under operational conditions often exhibit coexisting high-frequency noise components and spectral aliasing background textures, and defect targets typically exhibit characteristics such as small scale, weak contrast, and multi-class coexistence, posing challenges for automatic defect detection systems. To address this, we introduce concepts including wavelet decomposition, cross-attention, and U-shaped dilated convolution into the YOLO framework, proposing the YOLOv11-WBD model to enhance feature representation capability and semantic mining effectiveness.
View Article and Find Full Text PDFJ Nucl Med Technol
September 2025
Institute of Nuclear Medicine, First Faculty of Medicine, Charles University and the General University Hospital in Prague, Prague, Czech Republic;
The aim of the study was to validate a new method for semiautomatic subtraction of [Tc]Tc-sestamibi and [Tc]NaTcO SPECT 3-dimensional datasets using principal component analysis (PCA) against the results of parathyroid surgery and to compare its performance with an interactive method for visual comparison of images. We also sought to identify factors that affect the accuracy of lesion detection using the two methods. Scintigraphic data from [Tc]Tc-sestamibi and [Tc]NaTcO SPECT were analyzed using semiautomatic subtraction of the 2 registered datasets based on PCA applied to the region of interest including the thyroid and an interactive method for visual comparison of the 2 image datasets.
View Article and Find Full Text PDFExp Cell Res
September 2025
The Department of Hematology, The First Affiliated Hospital of Hainan Medical University, No.31 Longhua Road, Haikou City, Hainan Province, 570000, P.R. China. Electronic address:
Background: Nasopharyngeal carcinoma (NPC) is a kind of tumor disease with high malignant degree. CREPT expression was elevated abnormally in multi-cancers. However, the role and regulatory mechanism of CREPT in NPC remains unknown.
View Article and Find Full Text PDFBioinspir Biomim
September 2025
Mechanical Engineering, University of Massachusetts Dartmouth, 285 Old Westport Road, Dartmouth, Massachusetts, 02747-2300, UNITED STATES.
Harbor seals possess a remarkable ability to detect hydrodynamic footprints left by moving objects, even long after the objects have passed, through interactions between wake flows and their uniquely shaped whiskers. While the flow-induced vibration (FIV) of harbor seal whisker models has been extensively studied, their response to unsteady wakes generated by upstream moving bodies remains poorly understood. This study investigates the wake-induced vibration (WIV) of a flexibly mounted harbor seal-inspired whisker positioned downstream of a forced-oscillating circular cylinder, simulating the hydrodynamic footprint of a moving object.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
September 2025
Pharmacology and Toxicology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Gamal Abdel Nasser, 11835, New Cairo, Egypt.
Licochalcone A (LCA), a natural flavonoid with potent anti-inflammatory properties, has shown promise as a neuroprotective agent. However, its ability to cross the blood-brain barrier (BBB) and exert central effects remains underexplored. In this study, we demonstrate for the first time that LCA enhances cognitive function in a lipopolysaccharide (LPS)-induced neuroinflammatory mouse model and effectively penetrates the BBB.
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