Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
This study aimed to investigate the PPK of EF in largemouth bass after oral and intravenous administration based on a nonlinear mixed effect model. Samples were collected using the sparse sampling method at pre-designed time points determined by high-performance liquid chromatography with a fluorescent detector. The initial PK parameters were estimated by reference search and the calculation of a naïve pooled approach. The covariate model included a variation in body weight. The oral dose data were best fitted by a one-compartment model. The injection dose data were best fitted by a two-compartment model. The results demonstrated that body weight had no marked effect on the parameters of PPK. Finally, the bioavailability was calculated to be 12.24%. The area under the concentration-time curve/minimum inhibitory concentration was estimated to be ≥408.16, indicating that EF at 20 mg/kg has high effectiveness for aquatic pathogens.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108383 | PMC |
| http://dx.doi.org/10.3390/ani15101362 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nonlinear Transverse Conductivity in Antiferroic Types of Magnetic Toroidal Metal.
Phys Rev Lett
August 2025
Hokkaido University, Graduate School of Science, Sapporo 060-0810, Japan.
We have performed careful measurements of nonlinear transverse conductivity (NLTC) at zero field in the intermetallic compound HoAgGe with two distinct magnetic toroidal (MT) structures. Below 7 K (MT1 phase), the NLTC signal becomes observable and significantly increases with decreasing temperature, whereas between 7 and 11.6 K (MT2 phase), it remains nearly zero.
View Article and Find Full Text PDFPerformance enhancement of a wind driven PMSG using an artificial neural network based nonlinear backstepping controller.
PLoS One
September 2025
Electrical Engineering Department, Faculty of Engineering, Minia University, Minia, Egypt.
With the increasing demand for wind energy in the electric power generation industry, optimizing robust and efficient control strategies is essential for a wind energy conversion system (WECS). In this regard, this study proposes a novel hybrid control strategy for wind power systems directly coupled to a permanent-magnet synchronous generator (PMSG). The contribution of this work is to propose a control strategy design based on a combination of the nonlinear Backstepping approach for system stabilization according to Lyapunov theory and the application of artificial neural network to maximize energy harvesting regardless of wind speed fluctuations.
View Article and Find Full Text PDFBio-Inspired Synergistic Model Predictive Control for Control Reallocation and Reduced Computational Cost in a Hybrid Exoskeleton.
IEEE Trans Neural Syst Rehabil Eng
September 2025
Dynamic optimization is a versatile control tool to determine optimal control inputs in a redundantly actuated wearable robot. However, dynamic optimization requires high computational resources for real-time implementation. In this paper, we present a bio-inspired control approach, based on the principle of muscle synergies, to reduce the computational cost of optimization.
View Article and Find Full Text PDF[Mathematical programming in assessment of the postmortem interval under conditions of linearly varying external temperature].
Sud Med Ekspert
September 2025
Samara State Medical University, Samara, Russia.
Objective: To develop and implement a method for determining the postmortem interval and the marginal errors of its estimates under conditions of linearly varying external temperature in the format of an online application.
Material And Methods: A computer-assissted numerical search for the absolute minimum point of the objective function obtained from a system of nonlinear equations reflecting the results of double rectal or cranioencephalic thermometry of a corpse under conditions of linearly varying external temperature was carried out. The search algorithm was generalized to possible marginal errors in measuring the initial indicators of temperature and time.
Water hardness and digestive diseases: a large-scale population-based prospective cohort study.
Int J Surg
September 2025
Department of Data Science, City University of Hong Kong, Hong Kong, SAR, China.
Background: Water hardness, which refers to the level of dissolved calcium and magnesium salts, is of significant public health concern due to its potential impact on health. The association between water hardness and digestive diseases remains underexplored, with limited evidence from small-scale clinical studies. Given the rising prevalence of digestive disorders worldwide, large-scale cohort studies are needed to address this gap in the literature.
View Article and Find Full Text PDF