Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Rationale And Objectives: Accurate differentiation between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD) in type 2 diabetes mellitus (T2DM) patients is crucial for effective management. This study aims to evaluate the diagnostic value of ultrasound, particularly the renal artery resistive index (RRI), in distinguishing DN from NDRD in T2DM patients with early to mid-stage chronic kidney disease (CKD).
Materials And Methods: This retrospective study included 164 T2DM patients with renal disease who underwent renal biopsy. Patients were divided into a derivation group (137) and a validation group (27). Each group was further categorized into DN and NDRD subgroups based on biopsy results. Clinical, laboratory, and ultrasound data, including RRI and diabetic retinopathy (DR), were analyzed to differentiate DN from NDRD.
Results: RRI values were significantly higher in DN patients, with optimal cutoffs of ≥ 0.72 for CKD stages 1-2 and ≥ 0.74 for stage 3. Combining RRI with DR achieved a specificity and positive predictive value (PPV) of 100% for diagnosing DN, confirmed in the validation group.
Conclusions: This study emphasizes the need for distinct RRI cutoff values for T2DM patients in early and mid-stage CKD. Stage-specific RRI cutoffs, combined with DR, provide a reliable, non-invasive approach to distinguish DN from NDRD, enhancing clinical decision-making.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jcu.24084 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nomogram models for predicting sarcopenia in elderly Asian patients with type 2 diabetes.
Clinics (Sao Paulo)
September 2025
Ultrasound Department, Jinan People's Hospital, Laiwu District, Jinan City, Shandong Province, China.
Background: Sarcopenia is a prevalent but underrecognized complication in elderly patients with Type 2 Diabetes Mellitus (T2DM). Its complex etiology limits early diagnosis and intervention. This study developed and internally validated a nomogram for individualized sarcopenia risk assessment in this population.
View Article and Find Full Text PDFCurrent status of Liraglutide delivery systems for the management of type 2 diabetes mellitus.
Drug Deliv Transl Res
September 2025
Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan, 333031, India.
Diabetes is a metabolic disorder of increasing global concern. Characterized by constantly elevated levels of glucose, severe β-cell dysfunction, and insulin resistance, it is the cause of a major burden on patients if not managed with therapeutic and lifestyle changes. The human body is slowly developing tolerance to many marketed antidiabetic drugs and the quest for the discovery of newer molecules continues.
View Article and Find Full Text PDFBrain functional alterations in type 2 diabetes with obstructive sleep apnea patients: A multicenter resting-state fMRI study.
Sleep Med
August 2025
Department of Radiology Imaging Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, PR China. Electronic address:
Objective: This multicenter study aimed to investigate resting-state brain functional alterations in patients with type 2 diabetes mellitus (T2DM) comorbid with obstructive sleep apnea (OSA), and to elucidate the underlying neural mechanisms.
Methods: A total of 139 participants were enrolled from two centers, including 48 healthy controls (HCs), 46 T2DM patients, and 45 T2DM with OSA patients. Resting-state functional magnetic resonance imaging (rs-fMRI) was used to assess brain function using degree centrality (DC), amplitude of low-frequency fluctuation (ALFF), and seed-based functional connectivity (FC).
Pancreatic beta-cell secretory products in the diagnosis and risk stratification of gestational diabetes mellitus: a prospective longitudinal cohort study.
BMJ Open
September 2025
Neath Port Talbot Hospital, Port Talbot, Wales, UK.
Introduction: Gestational diabetes mellitus (GDM) is common in pregnancy and is increasing in prevalence. It is associated with an increased risk of maternal and perinatal complications if not diagnosed and managed early. Most guidelines suggest making a diagnosis of GDM using an oral glucose tolerance test (OGTT) between 24 and 28 weeks of pregnancy at which stage there still is an increased risk of complications.
View Article and Find Full Text PDFEffects of combination therapy with SGLT2 inhibitors and GLP-1 receptor agonists on CRT response and clinical outcomes in in type 2 diabetes mellitus patients receiving chronic anti-diabetic medications: A multicenter observational study.
Diabetes Res Clin Pract
September 2025
Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy; Pollution and Cardiovascular Diseases Research Centre, University of Campania "Luigi Vanvitelli", Naples, Italy.
Background: Type-2-diabetes-mellitus (T2DM) impairs outcomes in patients undergoing cardiac-resynchronization-therapy-with-defibrillator (CRTd).While both sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) have cardiovascular benefits, their combination impact in CRTd-treated T2DM patients remains unclear.
Methods: In this prospective multicenter observational study, 2,257 T2DM patients treated with CRTd were stratified into three groups: SGLT2i monotherapy (n 874), GLP-1RAs monotherapy (n 808), and combination therapy with GLP-1RAs/SGLT2i (n 575).