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The advent of clinical language models integrated into electronic health records (EHR) for clinical decision support has marked a significant advancement, leveraging the depth of clinical notes for improved decision-making. Despite their success, the potential vulnerabilities of these models remain largely unexplored. This paper delves into the realm of backdoor attacks on clinical language models, introducing an innovative attention-based backdoor attack method, BadCLM (Bad Clinical Language Models). This technique clandestinely embeds a backdoor within the models, causing them to produce incorrect predictions when a pre-defined trigger is present in inputs, while functioning accurately otherwise. We demonstrate the efficacy of BadCLM through an in-hospital mortality prediction task with MIMIC III dataset, showcasing its potential to compromise model integrity. Our findings illuminate a significant security risk in clinical decision support systems and pave the way for future endeavors in fortifying clinical language models against such vulnerabilities.
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JMIR Res Protoc
September 2025
Department of Development & Environmental Studies, Palacký University Olomouc, Olomouc, Czech Republic.
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Institute of Hospital Management, Peking University Third Hospital, Beijing, China.
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J Neurol
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Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
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Eur J Neurol
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Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
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View Article and Find Full Text PDFTurk Kardiyol Dern Ars
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Department of Cardiology, Muğla Sıtkı Koçman University, School of Medicine, Muğla, Türkiye.
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