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Emissions from the upper-atmospheric molecular ion have been used to study the global-scale interactions of Jupiter, Saturn and Uranus with their surrounding space environments for over 30 years, revealing the processes shaping the aurorae. However, despite repeated attempts, and contrary to models that predict it should be present, this ion has proven elusive at Neptune. Here, using observations from the James Webb Space Telescope, we detect at Neptune, as well as distinct infrared southern auroral emissions. The average upper-atmosphere temperature is a factor of two cooler than those derived 34 years ago by Voyager 2, showing that the energy balance of this region is regulated by physical processes acting on a timescale shorter than both Neptunian seasons (40 yr) and the solar cycle.
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http://dx.doi.org/10.1038/s41550-025-02507-9 | DOI Listing |
J Chem Inf Model
September 2025
Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721-0041, United States.
The development of low-cost, high-performance materials with enhanced transparency in the long-wavelength infrared (LWIR) region (800-1250 cm/8-12.5 μm) is essential for advancing thermal imaging and sensing technologies. Traditional LWIR optics rely on costly inorganic materials, limiting their broader deployment.
View Article and Find Full Text PDFIn Silico Pharmacol
September 2025
Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S Nagar, Mohali, Punjab 160062 India.
Unlabelled: The global health crisis caused by SARS-CoV-2 underscores the urgent need for effective antiviral therapeutics. The SARS-CoV-2 main protease (Mpro) is a crucial enzyme in viral replication, making it a prime target for drug development. In this study, we designed and evaluated peptide inhibitors targeting Mpro by introducing systematic mutations in the Nsp10/11 cleavage site peptide (QLMPER).
View Article and Find Full Text PDFChem Biol Interact
September 2025
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:
Prolyl endopeptidase (PREP) drives neurodegenerative diseases through dual mechanisms involving enzymatic activity and protein-protein interactions (PPIs), yet current inhibitors predominantly target single pathways. Prolyl endopeptidase (PREP) fuels neurodegeneration via enzymatic cleavage and pathological PPIs, yet current inhibitors usually target only one facet. In this study, leveraging our developed high-sensitivity and high-specificity near-infrared fluorescent probe Z-GP-ACM, we established and validated a screening platform for PREP inhibitors with mouse brain S9 instead of the human recombinant PREP.
View Article and Find Full Text PDFCarbohydr Polym
November 2025
Engineering Technology Research Center of Drug Carrier of Guangdong, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan Un
Recently, a variety of stimulus-responsive hydrogel platforms have been developed, specifically designed to respond to changes in physiological signals within the disease microenvironment. However, due to the restricted regulation of drug release behavior in vivo by such hydrogel systems, the precise control of drug release kinetics has not been achieved. Therefore, developing precise drug delivery platforms that enable programmable and "on-off" delivery remains a challenge in this field.
View Article and Find Full Text PDFAdv Healthc Mater
September 2025
Brain Center, Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, 430071, China.
Glioblastoma multiforme (GBM) continues to pose a significant challenge in the field of neuro-oncology primarily because of the limited penetration of therapeutics across the blood-brain barrier (BBB) and the presence of immunosuppressive tumor microenvironments. To address these challenges, a HD-PEG@BM biomimetic nanoplatform (hereinafter referred to as HD-P@BM) is developed that cloaks the near-infrared II photosensitizer HD-PEG (HD-P) inside microglial membranes to enable enhanced BBB penetration and tumor-targeted delivery. In this study, it is found that the microglia-derived membranes enhanced the uptake of nanoparticles by both the glioma cells and tumor-associated microglia.
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