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Purpose Of The Review: Lumbar epidural steroid injections (ESIs) have been used for decades for managing lumbosacral pain, particularly in patients with radiculopathy and chronic low back pain. Despite frequent use, there remains debate regarding their overall effectiveness, fueled by variability in physician technique and differing opinions on the optimal approach. This narrative review examines the three primary methods of lumbar ESI administration-transforaminal, interlaminar, and caudal-to evaluate their respective advantages, limitations, and clinical applications.
Summary: Each ESI technique offers unique benefits and potential risks. The transforaminal approach provides targeted delivery to affected nerve roots but is associated with higher risks of complications such as nerve injury or vascular compromise. The interlaminar approach allows broader spread of injectate with a lower technical complexity but may lack precision in targeting the specific source of pain. The caudal approach, typically reserved for patients with altered spinal anatomy or prior lumbar surgery, offers the safest trajectory but often the least precise medication delivery. Outcomes with ESIs are highly variable, which contributes to the ongoing debate about their role in lumbosacral pain management.
Conclusion: Understanding the technical differences, risk profiles, and clinical indications of each lumbar ESI approach can help guide treatment planning and optimize outcomes. By tailoring the injection technique to the individual patient's anatomy and clinical presentation, physicians may improve both the efficacy and safety of epidural steroid injections in the treatment of lumbosacral pain.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103295 | PMC |
http://dx.doi.org/10.52965/001c.138210 | DOI Listing |
Am J Phys Med Rehabil
September 2025
University of Rochester Medical Center, Department of Physical Medicine and Rehabilitation, 601 Elmwood Ave, Rochester, NY 14642.
Objective: The purpose of this study was to evaluate the effect of transforaminal epidural steroid injection (TFESIs) for patients with lumbosacral radiculopathy secondary to a lumbosacral herniated nucleus pulposus (HNP).
Design: A retrospective review of adult patients who received a fluoroscopically guided TSNRI for a HNP was performed. Patient Reported Outcome Measurement Information System (PROMIS) domains of Physical Function (PF), Pain Interference (PI), and Depression (D) were collected at baseline and post-procedure short-term (1-3 months post-procedure) and long-term follow-up (6-12 months post-procedure).
Interv Pain Med
September 2025
Columbia University, Vagelos College of Physicians and Surgeons, USA.
Interv Pain Med
September 2025
Department of Anesthesiology, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
Background: There is debate about whether a standalone anteroposterior (AP) view can distinguish epidural contrast from non-epidural contrast spread.
Objectives: This study aims to assess the accuracy of the AP (anteroposterior) and Contralateral Oblique (CLO) views in distinguishing epidural contrast spread patterns from non-epidural contrast spread patterns.
Methods: Patients undergoing lumbar epidural steroid injections consented to participate in the study.
J Pers Med
August 2025
Department of Anesthesiology and Pain Medicine, College of Medicine, Ewha Womans University, Seoul 07985, Republic of Korea.
: Sarcopenia is defined by the progressive loss of muscle mass, strength, and/or physical performance associated with aging. Radiofrequency ablation (RFA) of the medial branch nerves is a well-established and effective treatment for lumbar facetogenic pain. While sarcopenia is associated with poor outcomes following epidural steroid injections and lumbar spine surgeries, its impact on clinical outcomes in patients undergoing RFA for facetogenic pain remains unexplored.
View Article and Find Full Text PDFBMC Neurol
August 2025
Spinal Cord Injury Center, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.
Introduction: Epidural steroid injection (ESI) is commonly performed in the outpatient setting for relieving lumbosacral radicular pain, i.e., sciatica.
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