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http://dx.doi.org/10.1002/mds.30227 | DOI Listing |
Mov Disord
August 2025
Institute of Human Genetics, Technical University of Munich, School of Medicine and Health, Munich, Germany.
Bioorg Med Chem
May 2020
Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China. Electronic address:
Malignant melanoma (MM) presents as the highest morbidity and mortality type in skin cancer. Herein, inspired by the previously reported anti-melanoma effect of propranolol, a widely applied β adrenergic receptor antagonist as cardiovascular drug, we set out to exploit its potential as anti-melanoma therapy based on the drug repurposing strategy. Structural optimization of propranolol yielded 5m, which exhibits dramatically improved potency on human melanoma cell growth (1.
View Article and Find Full Text PDFNeurol Sci
December 2003
Multiple Sclerosis Study Center, Gallarate Hospital, Via Pastori 4, I-21013, Gallarate (VA), Italy.
The recent re-discovery of axonal damage in multiple sclerosis has led to a renewed interest in neurodegenerative mechanisms of the disease. Transected or injured axons release several molecules from their proximal extremity into the intercellular space. Although these molecules can be measured, however, a biological marker of axonal and neuronal degeneration is still lacking.
View Article and Find Full Text PDF