Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Clostridium difficile, traditionally recognized as a cause of antibiotic-associated colitis, has emerged as a potential oncogenic factor in colorectal cancer (CRC). This article explores the mechanisms by which C. difficile toxins, TcdA and TcdB, contribute to CRC pathogenesis through epithelial barrier disruption, DNA damage, and chronic inflammation via NF-κB and STAT3 activation. Dysbiosis further exacerbates tumorigenesis by altering microbial metabolites. Understanding these interactions highlights potential therapeutic strategies, including toxin-neutralizing antibodies, fecal microbiota transplantation, and anti-inflammatory interventions, to mitigate CRC risk associated with C. difficile.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103445 | PMC |
| http://dx.doi.org/10.1007/s12672-025-02742-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
infection and antibiotic prescribing at a regional hospital in Australia: a case-control study.
Antimicrob Steward Healthc Epidemiol
September 2025
National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT, Australia.
Background: infections (CDI) increased at a large, regional hospital in New South Wales, Australia, in 2021, coinciding with an increase at hospitals Australia wide. We aimed to investigate the association between antibiotic prescribing practices and hospital-acquired CDI at the hospital to inform antimicrobial stewardship (AMS) programs.
Methods: We conducted a retrospective case-control study for the period July 1, 2018, and June 30, 2022.
Ceftobiprole medocaril (Zevtera) - a new cephalosporin antibiotic.
Med Lett Drugs Ther
September 2025
Profiling of Volatile Organic Compounds in Clinical Isolate Cultures and Stools from Children with Clostridioides difficile Infection by HS-SPME-GC-MS.
J Breath Res
September 2025
Shanghai Children's Hospital, 355 Luding Road, Shanghai, 200040, CHINA.
Bacterial volatile organic compounds (VOCs) have been investigated as non-invasive approaches for the diagnosis of infectious diseases. Here, we aimed to explore potential diagnostic markers by profiling VOCs in cultures of unique clinical Clostridioides difficile (C. difficile) isolates and stool samples from pediatric patients with C.
View Article and Find Full Text PDFTreatment outcomes and risk factors for severity and mortality in Clostridioides difficile infection: a single-center study in Thailand.
J Infect Dev Ctries
August 2025
Division of Infectious Disease, Department of Internal Medicine, Phramongkutklao Hospital and Phramongkutklao College of Medicine, Bangkok 10400, Thailand.
Introduction: Clostridioides difficile often causes hospital-acquired diarrhea, leading to unfavorable treatment outcomes. This study investigates CDI treatment outcomes and factors affecting severity and mortality at a university hospital in Thailand.
Methodology: A retrospective study was conducted from June 2019 to December 2021.
Doing more with less: a narrative review of recent evidence in diagnostic stewardship.
Curr Opin Infect Dis
September 2025
Department of Microbiology, Royal Melbourne Hospital.
Purpose Of Review: Diagnostic stewardship (DS) aims to optimise the use of laboratory testing to improve patient care while reducing unnecessary tests. This review examines recent evidence on DS interventions to optimise the use of resources, focusing on three key areas: reducing unnecessary testing, maximising the impact of existing tests, and avoiding the overdiagnosis of hospital-acquired infections.
Recent Findings: Multiple interventions have demonstrated effectiveness in reducing unnecessary blood and urine culture testing, including clinical decision support tools, education programs, and multidisciplinary approaches.