Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Monascus-fermented coix seed exhibits enhanced tocopherol accumulation compared to other strains, yet mechanisms remain unclear. Whether Monascus metabolites/enzymes drive this enrichment is worth exploring. Comparative genomics and transcriptomics were employed to analyze secondary metabolite profiles and tocopherol enrichment capabilities across Monascus strains. The results revealed that γ-aminobutyric acid (GABA) derived from amino acid metabolism is channeled into both the Shikimate pathway to generate homogentisic acid (a tocopherol precursor) and the Mevalonate pathway to produce ergosterol and geranylgeranyl diphosphate (another precursor). Furthermore, the total tocopherol content of M1 and M1 + 3 reached 168 and 148 μg/g DW, positively correlating with ergosterol content (p < 0.05). Transcriptomic data further demonstrated strain-specific differences in tocopherol enrichment, linked to upregulated expression of key genes (HPPD, ERG4, MVD, FDPS, GGPS1) governing precursor biosynthesis. Crucially, we validated that ergosterol acts as a stimulator of tocopherol synthesis, directly supporting our hypothesis on pathway crosstalk. This study elucidates microbial-driven tocopherol enrichment mechanisms via precursor allocation and transcriptional regulation, providing insights into bioactive compound synthesis in complex metabolic networks.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.foodchem.2025.144860 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Grape Molasses as a Healthy Natural Ingredient in Hazelnut Butter: Effects on Emulsion Stability, Physicochemical, Nutritional, and Sensory Characteristics.
ACS Omega
August 2025
Department of Food Engineering, Faculty of Agriculture, Ordu University, Ordu 52200, Türkiye.
This study investigated the emulsion stability, physicochemical properties, nutritional content, and sensory characteristics of hazelnut butter formulations () enriched with grape molasses () as alternative to starch-based refined sugar () or beet sugar both with and without palm oil stabilizer () and skimmed milk powder (). The incorporation of increased the Hunter *, *, and * values, while and generally reduced color values and increased % ( < 0.05).
View Article and Find Full Text PDFSynthesis and biological evaluation of α-D-tocopherol derivatives as anticancer agents targeting mitochondrial metabolism.
Eur J Med Chem
August 2025
Department of Biomedical Sciences, Graduate School of Medical Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea; Graduate School of Clinical Drug Discovery & Development, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seou
Cancer, driven by mitochondrial and nuclear DNA mutations, presents opportunities for targeted therapies. Gastric cancer (GC), the 4th leading cause of cancer-related deaths, has poor prognosis due to cancer stem cells (CSCs), which depend on mitochondrial complex II (CII) respiration. Among CSC-enriched subtypes, the aggressive stem-like/EMT/Mesenchymal (SEM) GC subtype exhibits high plasticity, chemotherapy resistance, and metabolic adaptations that promote tumor survival.
View Article and Find Full Text PDFEffect of Hemp Protein and Sea Buckthorn Extract on Quality and Shelf Life of Cooked-Smoked Sausages.
Foods
August 2025
Department of Energy Saving and Automation, Kazakh National Agrarian Research University, Almaty 050010, Kazakhstan.
Modern meat processing faces several challenges, including high resource consumption, environmental impact, and the need to enhance the nutritional and biological value of finished products. In this context, interest is growing in functional plant-based ingredients capable of improving the quality of meat products. The aim of this study was to evaluate the effect of adding 0.
View Article and Find Full Text PDFUnveiling multifunctional bioactive phytochemicals and antioxidants in tangerine pomace for value-added applications.
Food Chem
August 2025
School of Chemical Engineering, Sungkyunkwan University, 2066, Seobu-Ro, Jangan-Gu, Suwon, Gyeong Gi-Do 16419, Republic of Korea; School of Mechanical Engineering, Sungkyunkwan University, 2066, Seobu-Ro, Jangan-Gu, Suwon, Gyeong Gi-Do 16419, Republic of Korea; SKKU Advanced Institute of Nano Techno
Tangerine pomace (TGP), a byproduct of juice processing, holds great potential as a source of health-promoting phytochemicals. Its chemical complexity, however, requires high-resolution analytical techniques and tailored solvent strategies for effective extraction. This study utilized comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC × GC-TOF-MS) and other advanced instrumentations to thoroughly profile solvent-specific phytochemicals extracted with ethanol and n-hexane.
View Article and Find Full Text PDFAlpha-tocopheryl quinone attenuates liver fibrosis through enriching Christensenella minuta and modulating bile acids metabolism via gut-liver axis.
Phytomedicine
October 2025
Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China. Electronic address:
Background: Liver fibrosis, characterized by the progressive accumulation of excessive extracellular matrix (ECM), remains a major global health issue with limited treatment options. The gut-liver axis, particularly the dynamics of gut microbiota and bile acids (BAs), plays a pivotal role in modulating hepatic fibrogenesis. Alpha-tocopheryl quinone (TQ), a vitamin E metabolite, exhibits antioxidative and anti-inflammatory properties; however, its impact on liver fibrosis remains unexplored.
View Article and Find Full Text PDF