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http://dx.doi.org/10.3389/fmicb.2025.1604849 | DOI Listing |
Biomacromolecules
September 2025
Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Teknikringen 58, Stockholm 10044, Sweden.
Lignin, traditionally considered a low-value byproduct of the pulp and paper industry, has gained significant attention in recent years as a sustainable precursor for the development of functional materials. This paradigm shift is driven by recent studies exploring the structure-property-performance relationships of lignin-based functional materials, which have provided valuable insights for selective chemical functionalization or pretreatment of lignin. Furthermore, the use of complementary analytical techniques has helped to shed light into lignin's complex and heterogeneous structure, opening new avenues for chemical modification.
View Article and Find Full Text PDFAm J Pharm Educ
September 2025
Department of Pharmacotherapy, University of Utah College of Pharmacy, 30 South 2000 East, Salt Lake City, Utah 84112. Electronic address:
The accelerating adoption of artificial intelligence (AI), particularly large language models (LLMs) such as ChatGPT, has raised critical questions about the role of pharmacists and the potential for AI to substitute for human expertise in pharmaceutical care. Grounded in Porter's Five Forces framework-specifically the threat of substitutes-this commentary explores whether AI can adequately fulfill the complex and relational functions of pharmacists in delivering care to patients. Drawing from foundational definitions of pharmaceutical care and economic theories of substitution, the paper examines both historical and emerging competitors to pharmacist-provided services, including physicians, nurses, and now AI-powered tools.
View Article and Find Full Text PDFNeurol Ther
September 2025
Department of Neurology, Neurocritical Care, and Neurorehabilitation, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Paracelsus Medical University, Member of ERN EpiCARE, 5020, Salzburg, Austria.
Introduction: Migraine headache not only is associated with high levels of suffering but also represents a considerable socioeconomic challenge. It is linked to various psychological and physiological impairments, including sensorimotor and somatosensory dysfunction, like those observed in other persistent pain syndromes. This study aims to determine whether individuals with high-frequency episodic (HFEM) or chronic migraine (CM) exhibit differences in somatosensory perception compared to healthy individuals and to explore potential correlations with neuropsychological features.
View Article and Find Full Text PDFCell Mol Life Sci
September 2025
Department of Neurology, The Second Affiliated Hospital of Xinjiang Medical University, Ürümqi, 830054, Xinjiang, China.
Microglial activation-induced neuroinflammation and impaired neuronal mitophagy are recognized as pivotal pathogeneses in Parkinson's disease (PD). However, the role of microglial mitophagy in microglial activation during PD development remains unclear, and therapeutic interventions targeting this interaction are lacking. Rhapontigenin (Rhap), a stilbenoid enriched in Vitis vinifera, exhibits dual anti-neuroinflammatory and mitophagy-enhancing properties, but its therapeutic potential and mechanisms in PD are unexplored.
View Article and Find Full Text PDFJ Ethnopharmacol
September 2025
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China. Electronic address:
Ethnopharmacological Relevance: Naoxintong, a Chinese patent medicine, may serve as an adjunctive therapy for the secondary prevention of ischemic stroke.
Aim Of The Study: To assess the effectiveness and safety of Naoxintong in preventing recurrent ischemic stroke and to review its preclinical evidence.
Materials And Methods: A search of electronic databases and registries was performed to locate relevant randomized controlled trials (RCTs) on Naoxintong for preventing ischemic stroke recurrence and animal studies exploring its mechanisms in atherosclerosis improvement.