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The leaky integrate-and-fire (LIF) model provides a fundamental framework for modeling neuronal dynamics in spiking networks. While generalized LIF models can incorporate features, such as spike-frequency adaptation and noise, our study specifically examines its fractional-order extension governed by a relaxation equation with a fractional derivative, whose power-law dynamics emulate long-term memory effects ideal for processing intermittent, scale-invariant signals. Statistical properties of the response of the fractional-order LIF model to a flickering input voltage pulse flow, characterized by a fractional Poisson process of order ν, are evaluated. To implement the fractional LIF model in hardware, we developed a microscale transistor using a network of single-walled carbon nanotubes with an electrolyte gate. The system exhibits fractional-order dynamics, making it well-suited for neuromorphic spiking networks that process scale-invariant signals with long-range temporal correlations.
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http://dx.doi.org/10.1063/5.0251233 | DOI Listing |
Sci Rep
September 2025
Laboratory of Animal Morphology, Department of Animal Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, 464-8601, Aichi, Japan.
During early pregnancy in mice, leukemia inhibitory factor (LIF) regulates embryo implantation by activating the JAK/STAT3 signaling pathway. The STAT3 pathway has been recognized to play a critical role in embryo implantation; however, it remains unclear whether STAT3 activation alone is sufficient to induce implantation. In this study, we investigated the effects of RO8191, a potential STAT3 activator, on embryo implantation through a series of studies with different mouse models.
View Article and Find Full Text PDFSci Total Environ
September 2025
Laboratory of Plant Molecular Physiology, Centre of Biotechnology of Borj-Cedria, PB.901, 2050, Hammam-Lif, Tunisia. Electronic address:
Climate change is challenging agriculture and food security due to the limited adaptability of domesticated crops. While plant range shifts along latitudinal and altitudinal gradients are well-documented, their impacts on belowground microbial communities and plant adaptability remain poorly understood. Vitis vinifera subsp.
View Article and Find Full Text PDFJ Phys Chem B
September 2025
Zhejiang Key Laboratory of Data-Driven High-Safety Energy Materials and Applications, Ningbo Key Laboratory of Special Energy Materials and Chemistry, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
This study developed a high-precision deep potential (DP) model based on density functional theory (DFT) and the DP-GEN workflow to efficiently simulate the microscopic structures and thermophysical properties of LiF-NaF-KF molten salt systems with varying compositions. Through iterative optimization of the training data set using the DP-GEN active learning strategy, our DP model demonstrated excellent agreement with DFT calculations in predicting energies, forces, and stresses. Leveraging this model, we systematically investigated the local structures and properties of 22 FLiNaK molten salt compositions, including radial distribution functions (RDFs), coordination numbers (CNs), density (ρ), heat capacity (), self-diffusion coefficients (SDCs), electrical conductivity, and shear viscosity.
View Article and Find Full Text PDFACS Omega
August 2025
Laboratoire Matériaux Avancés et Phénomènes Quantiques, Faculté des Sciences de Tunis, Université de Tunis El Manar, Campus Universitaire, Tunis 2092, Tunisia.
This paper reports the use of P18-8, a novel conjugated polymer combining poly-(1,4-phenylene-ethynylene) and poly-(1,4-phenylene-vinylene), in the fabrication of an organic diode with the structure ITO/PEDOT:PSS/P18-8/LiF/Al. The electrical properties of the fabricated device were characterized using impedance spectroscopy across a frequency range of 100 Hz to 1 MHz at various applied voltages. The current density-voltage (-) characteristic exhibited ohmic behavior at low applied voltages, while at higher voltages, it conformed to the space charge limited current (SCLC) theory.
View Article and Find Full Text PDFCNS Neurosci Ther
September 2025
Department of Anesthesiology, Northern Jiangsu People's Hospital, Yangzhou, China.
Aims: This study is to investigate the role of Endothelin-converting enzyme-like 1 (ECEL1) in neuropathic pain (NP).
Methods: The expression of ECEL1 was modulated by injecting adeno-associated virus 5 (AAV5) carrying Ecel1 shRNA or full-length Ecel1 into the dorsal root ganglion (DRG) of mice with a chronic constriction injury (CCI) model. Then, various nociceptive responses were evaluated.