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Article Abstract
Introduction: A comprehensive understanding of gene-diet interactions is necessary to establish proper dietary guidelines for the prevention and management of type 2 diabetes mellitus (T2DM). We examined the roles of genetic variants and their interactions with T2DM-associated nutrients in a large-scale genome-wide association study of Korean adults.
Methods: A total of 50,808 participants from a Korean genome and epidemiology study were included. Dietary intake was assessed using a food frequency questionnaire. Dietary nutrient intake was classified based on the Korean Dietary Reference Intakes (DRIs). Odds ratio (OR) and 95% confidence interval were calculated after adjusting for age, sex, exercise, smoking, alcohol consumption, total energy consumption, principal component 1, and principal component 2.
Results: Among the individuals consuming vitamin A (retinol equivalent) above the DRI, the carriers of the melanotransferrin () rs73893755 minor allele (T) had a higher risk of T2DM than the non-carriers (OR = 1.85, -value = 1.66 × 10; interaction -value = 7.61 × 10). Similarly, among the individuals consuming cholesterol (mg/day) above the DRI, the carriers of the tripartite motif-containing protein 25 () rs139560285 minor allele (A) had a higher risk of T2DM than the non-carriers (OR = 2.02, -value = 4.06 × 10; interaction -value = 4.28 × 10).
Discussion: Our results suggest that interactions between specific polymorphisms and certain nutrients may influence T2DM development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092224 | PMC |
| http://dx.doi.org/10.3389/fnut.2025.1538813 | DOI Listing |
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