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Background: Managing uncertainty is an essential element of patient-centered communication (PCC) and shared decision making (SDM), yet we know little about how residents' reactions to uncertainty are related to their perceptions of their ability to engage in these important activities. This longitudinal study assesses whether residents' self-perceived PCC and SDM skills are associated with their reactions to uncertainty throughout residency.
Methods: Data were collected using a three-year, longitudinal survey of two cohorts of pediatric residents. Before each year of residency, residents self-reported PCC behaviors (information exchange and socioemotional communication), SDM skills, and general intolerance of uncertainty, and context-specific reactions to uncertainty in patient care. 100 residents completed Phase I (intern year), 61 residents completed Phase II (second year), and 53 residents completed Phase III (third year).
Results: Anxiety from uncertainty and reluctance to disclose uncertainty to parents were significant, negative predictors of SDM perceptions at each phase. Anxiety from uncertainty negatively predicted PCC information-related behaviors (seeking, giving, and verifying) at each phase, but not socioemotional communication. At each phase, concerns for bad outcomes only significantly predicted information giving. Tolerance of uncertainty was not a significant predictor of SDM perceptions or any of the four dimensions of PCC.
Conclusions: Residents with stronger negative reactions to uncertainty reported poorer self-perceptions of patient-centered communication and shared decision making over the course of residency. Thus, residency programs should implement training that normalizes conversations about uncertainty and identifies strategies for PCC and SDM in situations of clinical uncertainty.
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http://dx.doi.org/10.1080/17538068.2025.2508359 | DOI Listing |
PLoS Biol
September 2025
Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Theoretical accounts postulate that the catecholaminergic neuromodulator noradrenaline shapes cognition and behavior by reducing the impact of prior expectations on learning, inference, and decision-making. A ubiquitous effect of dynamic priors on perceptual decisions under uncertainty is choice history bias: the tendency to systematically repeat, or alternate, previous choices, even when stimulus categories are presented in a random sequence. Here, we directly test for a causal impact of catecholamines on these priors.
View Article and Find Full Text PDFJ Chem Theory Comput
September 2025
Department of Chemical & Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.
Discovering chemical reaction pathways using quantum mechanics is impractical for many systems of practical interest because of unfavorable scaling and computational cost. While machine learning interatomic potentials (MLIPs) trained on quantum mechanical data offer a promising alternative, they face challenges for reactive systems due to the need for extensive sampling of the potential energy surface in regions that are far from equilibrium geometries. Unfortunately, traditional MLIP training protocols are not designed for comprehensive reaction exploration.
View Article and Find Full Text PDFJ Res Pharm Pract
August 2025
Pharmaceutical Care Administration, Armed Forces Hospital Southern Region, Khamis Mushait, Saudi Arabia.
Objective: This study evaluated pharmacists' and pharmacy technicians' knowledge, attitudes, and practices (KAPs) regarding pharmacovigilance and adverse drug reaction (ADR) reporting at a tertiary care facility in Saudi Arabia. It also sought to identify the barriers to ADR reporting and propose strategies to improve pharmacovigilance practices. This study is timely given recent initiatives by the Saudi Vision 2030 to strengthen medication safety practices nationwide.
View Article and Find Full Text PDFPLoS One
September 2025
Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America.
As a common experimental technique, qPCR (Quantitative Real-time Polymerase Chain Reaction) is widely used to measure levels of nucleic acids, e.g., microRNAs and messenger RNA.
View Article and Find Full Text PDFGlob Chang Biol
September 2025
State Key Laboratory of Wetland Conservation and Restoration, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, and Institute of eco-Chongming, School of Life Sciences, F
The thermal adaptation of the microbial community can potentially mitigate the positive feedback between soil carbon loss and climate change. However, the mechanistic basis of this process remains unclear, particularly the link between functional genes and microbial metabolic physiology in regulating the thermal response of soil carbon decomposition. While most experimental warming studies have examined elevated mean temperatures, the magnitude of temperature fluctuations is also increasing under climate change and may impose distinct ecological effects on microbial processes.
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