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Advances in evidence-based neonatal care have led to large improvements in the survival rates of high-risk newborns. Yet studies have documented wide variation in the care of more prevalent moderate-risk infants, who comprise a much larger proportion of admissions to neonatal care. In this study, we build on a small literature which uses quasi-experimental design to understand the impact of neonatal care, and for the first time, examine this moderate-risk cohort of infants. We use individual-level data on the full population of births in the state of New South Wales, Australia to examine the impact of neonatal care on the healthcare use of moderate-risk infants in the first two years of life. We implement a regression discontinuity design exploiting admission protocols based on birthweight among neonatal units of three different and explicit levels of capability. Unlike previous studies, which examine differences in outcomes across the high-risk cut-off at 1500 g, our study examines differences for moderate-risk infants born near birthweight cut-offs closer to normal birth weight (2500 g). While admission to the neonatal unit jumps across the cut-off, we find modest impacts on downstream healthcare use, including both in-hospital and out-of-hospital care. However, we identify heterogeneous effects across varying capability levels. Moderate risk infants admitted to lower capability neonatal units received more cost-intensive care, resulting in reduced healthcare use following discharge from hospital, while the same was not observed for those admitted to the highest capability units. We suggest that this is due to more aggressive clinical management at lower capability units, and leave this as a priority for future research.
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http://dx.doi.org/10.1016/j.jhealeco.2025.102995 | DOI Listing |
Kidney360
September 2025
Department of Pediatrics, Division of Pediatric Nephrology, Baylor College of Medicine, Houston, TX, United States.
Background: Dialysis in neonates with ESKD is often associated with multiple comorbidities and the need for more intensified dialysis regimens. With recent advances in prenatal interventions and infant specific KRT, survival of neonates with ESKD has improved over the last decade. Little is known however about the impact on the health care system of improved survival in this population.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Importance: Exposure to inflammation from chorioamnionitis places the fetus at higher risk of premature birth and may increase the risk of neurodevelopmental impairments, though the evidence for the latter is mixed.
Objective: To evaluate whether moderate to severe histologic chorioamnionitis (HCA) is directly associated with adverse motor performance, independent of the indirect mediating effects of premature birth.
Design, Setting, And Participants: This prospective, population-based cohort study recruited participants between September 16, 2016, and November 19, 2019, from referral and nonreferral neonatal intensive care units of 5 southwestern Ohio hospitals.
J Urban Health
September 2025
Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.
Timely access to comprehensive , high-quality emergency obstetric and neonatal care can prevent maternal and neonatal mortality but remains challenging in Benin. We examine geographic accessibility to childbirth care (CBC) in Grand Nokoué, the largest conurbation in Benin. We gathered data on boundaries, health facilities, road network, elevation, land cover, relative wealth, urbanicity, and geo-traced travel speeds over 45 days during the rainy season.
View Article and Find Full Text PDFKhirurgiia (Mosk)
September 2025
Children's City Clinical Hospital No. 9, named after G.N. Speransky, Moscow, Russia.
Background: The paper addresses an important section of pediatric combustiology - generalized meningococcal infection, associated with a severe course, the risk of disabling complications, life-threatening conditions, and high mortality.
Objective: The purpose of the study was to share the experience of treating patients with the sequelae of generalized bacterial infection caused by in a children's burn center.
Material And Methods: We conducted a retrospective analysis of the medical records of 23 patients treated in the burn department for babies from 0 to 3 years of the Children's City Clinical Hospital No.
J Perinat Neonatal Nurs
September 2025
Author Affiliations: Department of Radiodiagnosis, Livasa Hospital, Sahibzada Ajit Singh Nagar, India (Dr A. Yadav); Advanced Pediatric Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India (Drs Sivagnanaganesan, J. Yadav, J. Kumar); Department of Pediatrics, All India
Background And Objectives: In vitro studies suggest that oral zinc supplementation reduces enterohepatic circulation of unconjugated bilirubin and serum bilirubin levels. Multiple randomized controlled trials (RCTs) have assessed the efficacy of oral zinc supplementation in reducing bilirubin levels and the need for phototherapy. However, the evidence remains conflicting.
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