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http://dx.doi.org/10.1111/ceo.14558 | DOI Listing |
Clin Transl Oncol
September 2025
Ophthalmology Unit, Cannizzaro Hospital, 95126, Catania, Italy.
Antibody-drug conjugates (ADCs) represent a promising therapeutic approach in gynecologic cancers, particularly ovarian and cervical malignancies. Agents such as mirvetuximab soravtansine, and tisotumab vedotin, targeting folate receptor alpha and tissue factor, respectively, reported clinical efficacy in patients with limited options. However, their use is associated with ocular toxicities, including keratopathy, blurred vision, and dry eye, which may impact adherence and quality of life.
View Article and Find Full Text PDFBr J Dermatol
September 2025
Clinical Oncology, Guy's and Thomas' NHS Foundation Trust, London, uk.
Background: Primary Cutaneous CD4+ Small Medium T Cell Lymphoproliferative Disorder (PCSM-TLPD) is a rare subtype of indolent lymphoproliferative disease. The treatment, investigations and follow-up protocol are being re-evaluated.
Objective: To use our service evaluation to understand the presentation, response rate, relapse rate, treatment variation, progression free and overall survival of our cohort.
J Urol
September 2025
Department of Urology, University of Michigan, Ann Arbor, Michigan.
Purpose: We assessed the effects of vaginal lasers for treating stress urinary incontinence (SUI) in women.
Materials And Methods: This systematic review and meta-analysis included randomized trials of women with SUI and assessed therapy with vaginal laser vs sham, control, or topical treatments.
Results: Nine studies of 689 women with SUI were included.
Front Vet Sci
August 2025
Zoetis, Veterinary Medicine Research and Development, Kalamazoo, MI, United States.
Notoedric mange (also known as feline scabies) is a highly contagious and intensely pruritic dermatologic condition of cats caused by infestation with mites. Previous publications provide evidence that topical selamectin, and more recently, topical selamectin + sarolaner is efficacious in the treatment of notoedric mange in cats. The study reported here was conducted to confirm the efficacy of a topically applied combination of selamectin and sarolaner (Stronghold Plus) in the treatment of notoedric mange in cats naturally infested with Client-owned cats with clinical signs of notoedric mange and positive for live mites were enrolled and allocated randomly to treatment with either placebo ( = 10) or Stronghold Plus ( = 10).
View Article and Find Full Text PDFFront Pharmacol
August 2025
Department of Anorectal Medicine, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, China.
Background: Calcium channel blockers (CCBs) are first-line pharmacotherapy for chronic anal fissures (CAF), but the optimal administration route (oral vs. topical) remains unclear. This systematic review and meta-analysis compared efficacy and safety of oral vs.
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