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http://dx.doi.org/10.1186/s12951-025-03462-3 | DOI Listing |
J Nanobiotechnology
May 2025
Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Nat Commun
February 2025
School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.
Proc Natl Acad Sci U S A
May 2023
Department of Biochemistry, Teikyo University School of Medicine, Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
As a decoy receptor, soluble ST2 (sST2) interferes with the function of the inflammatory cytokine interleukin (IL)-33. Decreased sST2 expression in colorectal cancer (CRC) cells promotes tumor growth via IL-33-mediated bioprocesses in the tumor microenvironment. In this study, we discovered that hypoxia reduced sST2 expression in CRC cells and explored the associated molecular mechanisms, including the expression of key regulators of ST2 gene transcription in hypoxic CRC cells.
View Article and Find Full Text PDFMol Biol Evol
June 2021
School of Biological Sciences, University of Nebraska, Lincoln, NE, USA.
Population genomic analyses of high-altitude humans and other vertebrates have identified numerous candidate genes for hypoxia adaptation, and the physiological pathways implicated by such analyses suggest testable hypotheses about underlying mechanisms. Studies of highland natives that integrate genomic data with experimental measures of physiological performance capacities and subordinate traits are revealing associations between genotypes (e.g.
View Article and Find Full Text PDFInt J Mol Sci
August 2020
Department of Biomedicine, Neurosciences and advanced Diagnostics (Bi.N.D), University of Palermo, via Divisi 83, 90133 Palermo, Italy.
The correct concentration of oxygen in all tissues is a hallmark of cellular wellness, and the negative regulation of oxygen homeostasis is able to affect the cells and tissues of the whole organism. The cellular response to hypoxia is characterized by the activation of multiple genes involved in many biological processes. Among them, hypoxia-inducible factor (HIF) represents the master regulator of the hypoxia response.
View Article and Find Full Text PDF