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Background: Limited literature exists on how concurrent substance use and difficulty meeting basic needs impact recent psychiatric treatment among people who inject drugs (PWID) with diagnosed mental health disorders in the U.S. This study assessed the prevalence of taking current psychiatric medication treatment, and its association with concurrent substance use and subsistence difficulty.
Method: Baseline data from a prospective cohort study in Los Angeles, CA and Denver, CO between April 2021 and November 2022 were analyzed. Modified Poisson regression assessed the association between demographics, concurrent substance use, subsistence difficulty, and recent psychiatric medication treatment.
Results: Out of 429 PWID, 287 (66.9%) who reported a history of diagnosed mental health disorders were included. Among them, 86.8% of participants were unhoused or unstably housed, and 22.6% reported taking prescribed psychiatric medications in the past three months. Factors positively associated with current psychiatric medication treatment included older age (40-59: adjusted prevalence ratio [aPR] = 1.84, 95%CI: 1.15, 2.94); 60-76: aPR = 2.22, 95%CI: 1.21, 4.06; vs. 20-39 years old), non-medical prescription opioid use (aPR = 1.57, 95%CI: 1.06, 2.35), and recent overdose (aPR = 2.16, 95%CI: 1.45, 3.22). Conversely, being unhoused or unstably housed (aPR = 0.51, 95%CI: 0.29, 0.89) and high subsistence difficulty (aPR = 0.41, 95%CI: 0.21, 0.81) were less likely to take prescribed psychiatric medications.
Conclusion: A significant gap exists in psychiatric medication treatment among PWID with diagnosed mental health disorders. Integrated treatment programs addressing essential needs, such as food and clothing, alongside overdose prevention and mental health care, are urgently needed, particularly for those struggling with substance use and housing instability.
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http://dx.doi.org/10.1080/10826084.2025.2506135 | DOI Listing |
Circ Arrhythm Electrophysiol
September 2025
Department of Congenital Heart Disease, Evelina London Children's Hospital, United Kingdom (S. Chivers, T.V., V.Z., S.M., G.M., W.R., E.R., D.F.A.L., T.G.D., O.I.M., G.K.S., J.M.S.).
Background: Fetal tachycardias can cause adverse fetal outcomes including ventricular dysfunction, hydrops, and fetal demise. Postnatally, ECG is the gold standard, but, in fetal practice, echocardiography is used most frequently to diagnose and monitor fetal arrhythmias. Noninvasive extraction of the fetal ECG (fECG) may provide additional information about the electrophysiological mechanism and monitoring of intermittent arrhythmias.
View Article and Find Full Text PDFTelemed J E Health
September 2025
VA Puget Sound Health Care System, Seattle, Washington, USA.
The Veterans Health Administration (VHA) Clinical Resource Hubs (CRHs) provide telemental health (TMH) services to improve access for Veterans, but use varies greatly across clinics. A retrospective FY23 analysis examined all VHA outpatient mental health encounters. Clinics were categorized by CRH-MH use and level of CRH-MH penetration.
View Article and Find Full Text PDFGenes Brain Behav
October 2025
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Major depressive disorder is a prevalent and debilitating psychiatric illness that produces significant disability. Clinical data suggest that the pathophysiology of depression is due, in part, to a dysregulation of inflammation and glutamate levels in the brain. The systemic administration of lipopolysaccharide (LPS) has been shown to induce depressive-like behaviors in mice.
View Article and Find Full Text PDFBr J Psychiatry
September 2025
Neuroscience Research Australia, Randwick, New South Wales, Australia.
Background: Individuals with a family history of bipolar disorder are at increased risk of developing affective psychopathology. Longitudinal imaging studies in young people with familial risk have been limited, and cortical developmental trajectories in the progression towards illness remain obscure.
Aims: To establish high-resolution longitudinal differences in cortical structure that are associated with risk of bipolar disorder.
Epidemiol Psychiatr Sci
September 2025
Unit of Psychiatry, Department of Public Health and Medicinal Administration, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, MO, China.
Aims: Loneliness is a common public health concern, particularly among mid- to later-life adults. However, its impact on early mortality (deaths occurring before reaching the oldest old age of 85 years) remains underexplored. This study examined the predictive role of loneliness on early mortality across different age groups using data from the Health and Retirement Study (HRS).
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