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Background And Objective: Prolonged abnormal emotions can gradually evolve into mood disorders such as anxiety and depression, making it critical to study the relationship between emotions and mood disorders to explore the causes of mood disorders. Existing research on EEG-based emotion recognition and mood disorder detection typically treats these two tasks separately, missing potential synergies between them. The purpose is to reveal the relationship between emotions and mood disorders and propose a Multi-Task Residual Cross Attention Framework (MT-RCAF) to enhance both classification performances.
Methods: In MT-RCAF, the Feature Extraction module extracts specific and shared features for the corresponding tasks. The Residual Multi-head Cross Attention (RMCA) module dynamically adjusts attention weights to explicitly capture both shared and task-specific information, enhancing complementarity and feature sharing. The Gated Multi-embedding (GME) module filters out irrelevant features, improving task-specific performance. Finally, the Task Tower Classification module balances losses across tasks to facilitate both emotion recognition and mood disorder detection.
Results: We conducted experiments on the DEAP dataset as well as the self-collected Emotion and Mood Disorder Dataset (EMDD) to validate the effectiveness of MT-RCAF. The results show that the framework gains improvement in strongly correlated task groups, with average accuracy increases of 3.22% for emotion recognition and 3.91% for mood disorder detection, and in generally correlated task groups, with average accuracy increases of 2.87% for valence and 3.34% for arousal. The study also reveals that mood disorders (depression or anxiety) increase sensitivity to negative emotions, and intense emotions enhance mood disorder detection.
Conclusion: The study validates the relationship between emotions and mood disorders from a deep-learning perspective and finds that interconnected tasks result in more accurate and robust results.
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http://dx.doi.org/10.1016/j.cmpb.2025.108835 | DOI Listing |
Elife
September 2025
Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show that interleukin-6-like cytokine signaling from the gut to brain glial cells regulates sleep. Under healthy conditions, this pathway promotes wakefulness.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240.
Major depressive disorder affects millions worldwide, yet current treatments require prolonged administration. In contrast, ketamine produces rapid antidepressant effects by blocking spontaneous N-Methyl-D-Aspartate (NMDA) receptor signaling, which lifts the suppression of protein synthesis and triggers homeostatic synaptic plasticity. Here, we identify a parallel signaling pathway involving metabotropic glutamate receptor 5 (mGluR5) that promotes rapid antidepressant-like effects.
View Article and Find Full Text PDFFood Funct
September 2025
Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian Province 361021, PR China.
Depression is a widespread mental health condition associated with impaired neuroplasticity and disrupted brain-derived neurotrophic factor (BDNF)/TrkB signaling. Black mulberry, rich in anthocyanins, shows promise as a natural intervention for its anti-oxidative and anti-inflammatory profiles. This study evaluated the antidepressant-like effects of black mulberry anthocyanins in mice subjected to chronic mild stress (CMS).
View Article and Find Full Text PDFCureus
September 2025
Pediatrics, University of Nevada Reno School of Medicine, Reno, USA.
Goldenhar syndrome, a rare congenital condition, often presents with physical anomalies due to abnormal development of the first and second branchial arches, leading to facial and auricular malformations. However, the mental health challenges associated with this syndrome are often overlooked. This report describes the case of a 14-year-old Latino/Hispanic male child with Goldenhar syndrome and limited verbal communication, highlighting the complexities of managing both physical and psychological aspects of care after establishing follow-up with a pediatrician.
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