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http://dx.doi.org/10.1007/s00259-025-07343-7 | DOI Listing |
Retin Cases Brief Rep
September 2025
Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California of Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
Purpose: To describe a case of recalcitrant bilateral peripapillary pachychoroid syndrome (PPS) treated with high-dose (HD) intravitreal aflibercept injections.
Methods: Medical and imaging records were retrospectively evaluated. Multimodal imaging included ultra-widefield indocyanine green and fluorescein angiography and fundus autofluorescence.
Brain Commun
August 2025
Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, University of Manchester, Manchester M6 8FJ, UK.
The cortex of the brain is covered by three meningeal layers: the dura, the arachnoid, and the pia mater. Substantial discoveries have been made demonstrating the structural and functional relationships between these layers, and with other neighbouring structures such as the skull. Importantly, improved understanding of the meningeal lymphatic network places the meninges at the nexus of a cross talk between the brain, peripheral immune system, and the skull bone marrow.
View Article and Find Full Text PDFAm J Psychiatry
September 2025
Department of Psychiatry, School of Medicine, Yale University, New Haven.
This review examines ketamine's neurotoxic potential across preclinical and clinical studies. The authors synthesized data from preclinical models, then integrated findings from human clinical trials of esketamine and observational studies in recreational users. Animal studies have found that repeated or high-dose subanesthetic ketamine administration results in consistent excitotoxic neuronal damage and lasting cognitive deficits, especially in perinatal animals.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Microbiology and Parasitology, Faculty of Biology - Aquatic One Health Research Center (iARCUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Uropathogenic Escherichia coli (UPEC) are among the first pathogens to colonise in catheter and non-catheter-associated urinary tract infections. However, these infections are often polymicrobial, resulting in multi-species infections that persist by forming biofilms. Living within these highly antimicrobial tolerant communities, bacteria can establish intra- and inter-specific interactions, including quorum sensing (QS)-mediated signalling mechanisms, which play a key role in biofilm establishment and maturation.
View Article and Find Full Text PDFJ Am Podiatr Med Assoc
September 2025
§Aybars Kıvrak Orthopedics Clinic, Adana, Turkey.
Background: Pilon fractures refer to distal tibial fractures that may involve extra-articular, partial articular, or complete intra-articular components, most commonly caused by high-energy trauma. The choice between early (<72 hours) and delayed (>7 days) surgical fixation significantly impacts clinical outcomes. This study aimed to compare the effects of early vs.
View Article and Find Full Text PDF