Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Protein cages are ideal scaffolds for presenting proteins of interest (POIs), but controlled POI release remains challenging. We engineered the Mi3 protein cage with chemically inducible dimerization domains and a photocleavable protein, enabling controlled recruitment and release of POIs both and in cells.

Download full-text PDF

Source
http://dx.doi.org/10.1039/d5cc00808eDOI Listing

Publication Analysis

Top Keywords

controlled recruitment
8
recruitment release
8
proteins interest
8
engineering mi3
4
mi3 system
4
system controlled
4
release proteins
4
interest protein
4
protein cages
4
cages ideal
4

Similar Publications

Background: The loss of a loved one is a common yet stressful event in later life. Internet- and mobile-based interventions have been proposed as an effective treatment approach for individuals with prolonged grief.

Objective: The AgE-health study aimed to investigate the efficacy of an eHealth intervention, trauer@ktiv, in reducing prolonged grief symptoms in a sample of older adults.

View Article and Find Full Text PDF

Importance: Patients with inflammatory rheumatic diseases (IRDs) frequently experience psychological distress; however, access to psychological support remains limited.

Objective: To investigate the effectiveness of a digital psychological intervention for individuals with IRDs.

Design, Setting, And Participants: Participants aged 18 years or older were recruited across Germany between February 22 and June 4, 2024, if they had been diagnosed with rheumatoid arthritis, psoriatic arthritis, or systemic lupus erythematosus and reported psychological distress and reduced quality of life.

View Article and Find Full Text PDF

Purpose: The purpose of the study was to identify the safety and effectiveness of an accelerated (AR) versus conservative (CR) rehabilitation regimen following surgical repair of proximal hamstring tendon avulsions.

Methods: This prospective randomized controlled trial (RCT) allocated patients undergoing proximal hamstring tendon repair to either a braced, partial weight-bearing rehabilitation regime (CR = 30) or an accelerated, unbraced regime, which permitted full weight-bearing as tolerated (AR = 27). Patients were evaluated pre-operatively and at 6 weeks, 3 and 6 months post-surgery, via patient-reported outcome measures (PROMs), patient satisfaction and global rating of change (GRC) scores.

View Article and Find Full Text PDF

Virtual Reality for Analgesia During Intrauterine Device Insertion: Randomized Controlled Trial.

JMIR Serious Games

September 2025

Women's and Newborn Program, Monash Health, 246 Clayton Rd, Melbourne, 3168, Australia, 61 395946666.

Background: Intrauterine devices (IUDs) are safe and effective long-acting reversible contraceptive therapies that are also used as minimally invasive treatment for heavy menstrual bleeding, endometrial hyperplasia, and early-stage endometrial cancer. Despite many advantages, IUDs are underused predominantly due to patient discomfort. Although many techniques have been explored previously in the literature, there is currently little consensus on effective analgesic strategies.

View Article and Find Full Text PDF