Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Hydrogel scaffolds show high potential in tissue engineering due to excellent mechanical properties and biocompatibility. However, an inherent lack of conductivity limits its application in areas requiring electrical stimulation. To address this issue, chitosan (CS)/gelatin (Gel) scaffolds were prepared with various concentrations of multi-walled carbon nanotubes (MWCNTs). Results indicated that MWCNT incorporation significantly improved both the electrical conductivity and mechanical strength of the scaffolds, with the CS/Gel/0.3% MWCNTs scaffold demonstrating superior biocompatibility compared to other formulations. Additionally, fibroblasts seeded onto the scaffolds responded positively to electrical stimulation, showing increased proliferation and elevated expression of type I and type III collagen. These findings highlight the potential of CS/Gel/MWCNTs scaffolds to enhance wound healing in skin tissue engineering.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/bit.29025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lipid nanoparticles: Composition, formulation, and application.
Mol Ther Methods Clin Dev
June 2025
Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Lipid nanoparticles (LNPs) are lead non-viral vectors for delivering nucleic acids. LNPs can efficiently encapsulate nucleic acids, protect them from degradation, enhance cellular uptake and induce endosome escape, which show high transfection efficiency and low immunogenicity. In this review, we first introduce the LNP components, highlighting their critical roles in encapsulation, stability, delivery efficiency, and tissue tropism.
View Article and Find Full Text PDFProgress in immunoregulatory mechanisms during distraction osteogenesis.
Front Bioeng Biotechnol
August 2025
Department of Orthopaedic and Reconstructive Surgery/Pediatric Orthopaedics, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.
Distraction osteogenesis (DO) is an endogenous bone tissue engineering technique that harnesses the regenerative potential of bone and has been widely applied in limb lengthening, bone defect repair, and craniofacial reconstruction. The DO procedure consists of three distinct phases: the latency phase, the distraction phase, and the consolidation phase, each characterized by unique biological processes. In recent years, increasing attention has been directed toward the role of the immune system during DO.
View Article and Find Full Text PDFSustained Mg/Sr ion delivery from injectable silk fibroin hydrogels drives SCAP osteogenic differentiation.
iScience
September 2025
Department of Geriatric Dentistry, NMPA Key Laboratory for Dental Materials, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Biomaterials for Oral Disease, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.
This study highlights the biomedical relevance of injectable TS (tannic acid-silk fibroin)-Mg/Sr hydrogels in alveolar bone repair, particularly their prospective role as carriers for stem cells from the apical papilla (SCAPs) in tissue regeneration. By utilizing self-assembling silk material, noted for its favorable handling properties, we present a useful approach for single-wall bone defects, such as bone fenestration and fractures in the oral cavity. Furthermore, our findings regarding the involvement of the TRPM7 ion channel indicate a possible regulatory pathway for improving alveolar bone defect repair.
View Article and Find Full Text PDFUnravelling the molecular network structure of biohybrid hydrogels.
Mater Today Bio
October 2025
Leibniz Institute of Polymer Research Dresden, Division Polymer Biomaterials Science, Max Bergmann Center of Biomaterials Dresden, 01069, Dresden, Germany.
Glycosaminoglycan-based biohybrid hydrogels represent a powerful class of cell-instructive materials with proven potential in tissue engineering and regenerative medicine. Their biomedical functionality relies on a nanoscale polymer network that standard microscopy techniques cannot resolve. Here, we introduce an advanced analytical approach that integrates transmission electron microscopy, X-ray scattering, and computer simulations to directly and quantitatively characterize the nanoscale molecular network structure of these hydrogels.
View Article and Find Full Text PDFUtilizing biomaterials for laryngeal respiratory mucosal tissue repair in an animal model.
Biomater Biosyst
September 2025
ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Introduction: The airway mucosa plays a crucial role in protection and various physiological functions. Current methods for restoring airway mucosa, such as myocutaneous flaps or split skin grafts, create a stratified squamous layer that lacks the cilia and mucus-secreting glands of the native columnar-lined airway. This study examines the application of various injectable biopolymers as active molecules for a potential approach to regenerating laryngeal epithelial tissue.
View Article and Find Full Text PDF