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The field of artificial intelligence (AI) is expanding quickly. To mimic the structure and biological evolution of the human brain, AI was developed to enable computers to acquire knowledge and manipulate their surroundings. There have been notable developments in the use of AI in healthcare; it can enhance diagnosis and treatment in various medical specialties. The cost of prompt diagnosis and treatment is hampered by the absence of efficient, dependable, and reasonably priced detection and real-time monitoring. Smart health tracking systems integrating AI and nanoscience are an emerging frontier that solves these obstacles. Targeted delivery of drug systems, biosensing, imaging, and other diagnostic and therapeutic fields can widely benefit abundantly from nanoscience in healthcare. AI technology has the potential to expand biomedical applications by analyzing and interpreting biological data, speeding up drug discovery, and identifying novel molecules with predictive behavior. This review outlines the current obstacles and potential opportunities for delivering personal healthcare using AI-assisted clinical decision support systems.
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http://dx.doi.org/10.1039/d5na00032g | DOI Listing |
Environ Sci Technol
September 2025
Department of Biomedical Informatics, Harvard Medical School, 10 Shattuck St, Boston, Massachusetts 02115, United States.
Accurate attribution of the areas and populations impacted by climate-related events often relies on linear distance-based methods, where the study unit is assigned temperature data to the closest weather station. We developed a novel method and data pipeline that provides a grid-based measure of exposure to extreme heat and cold events called Grid EXposure (, enabling linkage to individual-level human health data at different spatial scales. GridEX automates the gathering of station-based climatological data and provides estimates of apparent temperature, offering a more comprehensive representation of human thermal comfort and perceived temperature.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
Department of Systems and Computer Engineering, Carleton University, Ottawa, ON, Canada. Electronic address:
Monitoring skeletal muscle contraction provides valuable information about the muscle mechanical properties, which can be helpful in various biomedical applications. This chapter presents a single-element flexible and wearable ultrasonic sensor (WUS) developed by our research group and its application for continuously monitoring and characterizing skeletal muscle contraction. The WUS is made from a 110-µm thick polyvinylidene fluoride piezoelectric polymer film.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
School of Forensic Science, National Forensic Sciences University, Gandhinagar, Gujarat, India.
Ingestible biosensors are a mix of advanced biomedical engineering, digital health and precision pharmacotherapy. These miniaturised electronic devices are encapsulated in biocompatible materials, which operate within gastrointestinal (GI) tract. This enables real-time monitoring of pharmacological and physiological parameters.
View Article and Find Full Text PDFFish Shellfish Immunol
September 2025
Department of Biology, The Gandhigram Rural Institute (Deemed to be University), Gandhigram, Dindigul, Tamil Nadu 624302, India.
The dynamic interaction between immune recognition molecules and signaling pathways in the innate immune response of Penaeus monodon to White Spot Syndrome Virus (WSSV) infection is unveiled in this study. Through comprehensive gene expression profiling, we demonstrate significant upregulation of key immune genes, including a specific C-type lectin and a defined ficolin isoform, in WSSV-infected hemocytes, underscoring their pivotal roles in pathogen recognition and antiviral defense. Leveraging advanced molecular techniques, we successfully expressed, purified, and characterized these recombinant proteins, revealing their time-dependent expression and high-affinity binding to lipopolysaccharides (LPS).
View Article and Find Full Text PDFEur J Med Chem
September 2025
State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, PR China. Electronic address:
The Werner syndrome RecQ helicase (WRN) has recently emerged as a novel synthetic lethality target for microsatellite instability-high (MSI-H) cancers. However, available WRN inhibitors or degraders is still lacking so far. Particularly, chemically designed probes capable of degrading WRN irrespective of microsatellite status remain unexplored.
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