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http://dx.doi.org/10.1158/1078-0432.CCR-25-0737 | DOI Listing |
Redox Biol
August 2025
Dept. of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; Animal Science Dept., Plants for Human Health Institute, North Carolina State University, Kannapolis, NC, USA; Dept. of Food and Nutrition, Kyung Hee University, Seoul, South Korea. Electronic address: gvalacc@ncs
Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders characterized by impairments in social communication, restricted interests, and repetitive behaviors. Although its etiology remains incompletely understood, increasing evidence suggests a multifactorial origin involving genetic alterations, immune dysregulation, and environmental exposures. The aim of this study was to investigate the redox-sensitive Nrf2 signaling pathway in primary dermal fibroblasts isolated from ASD patients.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Puls Med Association, 051885 Bucharest, Romania.
Oxidative stress is a defining and pervasive driver of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). As a molecular accelerant, reactive oxygen species (ROS) and reactive nitrogen species (RNS) compromise mitochondrial function, amplify lipid peroxidation, induce protein misfolding, and promote chronic neuroinflammation, creating a positive feedback loop of neuronal damage and cognitive decline. Despite its centrality in promoting disease progression, attempts to neutralize oxidative stress with monotherapeutic antioxidants have largely failed owing to the multifactorial redox imbalance affecting each patient and their corresponding variation.
View Article and Find Full Text PDFFront Immunol
April 2024
Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.
[This corrects the article DOI: 10.3389/fimmu.2022.
View Article and Find Full Text PDFOncol Rep
May 2024
Department of General, Visceral and Transplant Surgery, University Hospital Heidelberg, D-69120 Heidelberg, Germany.
Following the publication of the above article and a corrigendum that was published in October 2023 to address the issue of misplaced control β‑actin western blots comparing between Figs. 3 and 4A (doi: 10.3892/or.
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