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Purpose: Telemedicine is useful for home management of sleep disordered breathing (SDB). However, the number of patients with SDB is high and public resources are low. The aim of this pilot study, conducted by the Universities of Pisa and Palermo, was to assess whether an external Medical Center, based on telemonitoring, could help in the management of patients on home positive airway pressure (PAP) treatment.
Methods: The management model included the following professional figures: the sleep physician, the local home care provider performing diagnostic studies and home PAP titration, and the external Medical Center monitoring PAP therapy alerts. A dedicated App allowed patients to answer questionnaires, receive alerts and contact the external Medical Center. Data on mask leakage, hours of use and efficacy were available on a web platform. Patients were evaluated with videocalls at 1, 2 and 4 months and as needed.
Results: We enrolled 30 subjects, 27 patients received Continuous PAP and 3 patients received Bilevel devices. Five patients withdrew during titration and 1 during follow-up. The number of interventions for technical problems requested by patients to the external Medical Center was highly variable. During the titration phase the interventions required were 2.1 ± 2.0 (range 0-11), while during the 4-month follow-up they were 6.0 ± 4.5 (range 0-18). At the end of follow-up, 93% of patients were satisfied by the telemedicine protocol.
Conclusion: A model of telemedicine using an external Medical Center can help in the home management of patients with SDB during both home titration and long-term treatment. FISR2020IP_02014 Project (MUR). May 2021.
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http://dx.doi.org/10.1007/s11325-025-03358-4 | DOI Listing |
J Magn Reson Imaging
September 2025
Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
Background: Cerebrovascular reactivity reflects changes in cerebral blood flow in response to an acute stimulus and is reflective of the brain's ability to match blood flow to demand. Functional MRI with a breath-hold task can be used to elicit this vasoactive response, but data validity hinges on subject compliance. Determining breath-hold compliance often requires external monitoring equipment.
View Article and Find Full Text PDFInt J Technol Assess Health Care
September 2025
Evidence Synthesis Group, Population Health Sciences Institute, Faculty of Medical Sciences, https://ror.org/01kj2bm70Newcastle University, Newcastle upon Tyne, UK.
Objectives: The National Institute for Health and Care Excellence (NICE) in England introduced early value assessments (EVAs) as an evidence-based method of accelerating access to promising health technologies that could address unmet needs and contribute to the National Health Service's Long Term Plan. However, there are currently no published works considering differences and commonalities in methods used between Assessment Reports for EVAs.
Methods: This rapid scoping review included all completed EVAs published on the NICE website up to 23 July 2024.
Andrology
September 2025
Department of Urology, Peking University First Hospital, Beijing, China.
Background: Non-obstructive azoospermia represents the most severe form of male infertility. The heterogeneous nature of focal spermatogenesis within the testes of non-obstructive azoospermia patients poses significant challenges for accurately predicting sperm retrieval rates.
Objectives: To develop a machine learning-based predictive model for estimating sperm retrieval rates in patients with non-obstructive azoospermia.
Psychophysiology
September 2025
Department of Human Medicine, Institute for Systems Medicine, MSH Medical School Hamburg, Hamburg, Germany.
Obsessive-compulsive disorder (OCD) has been associated with altered performance monitoring, reflected in enhanced amplitudes of the error-related negativity in the event-related potential. However, this is not specific to OCD, as overactive error processing is also evident in anxiety. Although similar neural mechanisms have been proposed for error and feedback processing, it remains unclear whether the processing of errors as indexed by external feedback, reflected in the feedback-related negativity (FRN), is altered in OCD.
View Article and Find Full Text PDFClin Anat
September 2025
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
There are no standardized guidelines for reconstructive surgery of large temporal bone defects following lateral temporal bone resection for external auditory (acoustic) meatus carcinoma. Filling the defect with well-vascularized tissue is important for large tissue defects to promote wound healing and prevent infection postoperatively. Patients with malignant tumors of the external acoustic meatus requiring lateral temporal bone resection may sometimes necessitate postoperative adjuvant chemoradiotherapy.
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