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Article Abstract
Iron-mediated hydrogen atom transfer (HAT) cascade annulation for the synthesis of -fused indole and pyrrole is disclosed. This robust cascade annulation assembles intricate heterocyclic motifs, such as tetrahydropyrido[1,2-]indoles and tetrahydroindolizines, equivalent to a formal [4+2] cycloaddition. The synthetic utility of the developed protocol was showcased in the synthesis of substituted tricyclic and tetracyclic heterocycles as well as an analogue of the natural product tashiromine.
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