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The aim of this study was to evaluate the surgical outcomes, therapeutic efficacy, and psychological satisfaction of the Le Fort partial colpocleisis (LFC) procedure, an obliterative surgical treatment option, in elderly women with advanced apical prolapse, based on the 20-year surgical experience of a single surgeon. A retrospective cohort study was conducted on 81 women aged 60 and older who underwent LFC for advanced apical prolapse at a single institution from 2006 to 2025. Baseline characteristics, comorbidities, perioperative outcomes, complications, and patients' satisfaction were analyzed. Among the patients, 86.4% were aged 70 or older, and also 85.2% of the women had comorbidities that could influence surgical outcomes. The surgical success rate was 96.3%, with recurrences observed in three cases. The median operative time was 89 min, but it decreased to median 77 min as the accumulated surgeon's experience. Similarly, hospitalization duration and patient-reported postoperative pain score also showed significant reductions. Transient postoperative complications were minimal, predominantly transient urinary symptoms (voiding difficulty in 4.9%, urinary frequency in 6.2%, and urinary incontinence in 3.7% of the patients). Satisfaction with the surgical treatment was high, with 98.4% reporting overall satisfaction. LFC is a safe and effective option for elderly women with advanced apical prolapse, offering high satisfaction rates and low morbidity. Surgeon's experience significantly enhances outcomes after about 20 cases. Careful patient selection and throughout counseling are essential to optimize outcomes and address patients' satisfaction by enhancing physical and psychological quality of life.
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http://dx.doi.org/10.3390/jcm14093101 | DOI Listing |
Circulation
September 2025
Cardiology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Italy (M.P.M).
Cardiac adipose tissue is normally present in the epicardium, but a variable amount can also be present in the myocardium, particularly in the subepicardial regions of the right ventricular anterolateral and apical regions. Pathological adipose tissue changes may occur in both ischemic (previous myocardial infarction) and nonischemic (previous myocarditis, arrhythmogenic cardiomyopathy, lipomatous hypertrophy of the interatrial septum, cardiac lipomas and liposarcomas) conditions, with or without extensive replacement-type myocardial fibrosis. Cardiac magnetic resonance is the gold standard imaging technique to characterize myocardial tissue changes and to distinguish between physiological and pathological cardiac fat deposits.
View Article and Find Full Text PDFWorld J Methodol
December 2025
Department of Periodontics, Sudha Rustagi College of Dental Sciences and Research, Faridabad 121002, Haryāna, India.
Background: Advanced materials and techniques are used to successfully manage the apexification of immature teeth with open apices. The use of mineral trioxide aggregate (MTA), bioceramic sealers, and sodium hypochlorite (NaOCl), combined with internal heating and ultrasonic activation, ensures that canals are cleaned, disinfected, and sealed properly. Magnification devices, such as dental operating microscopes (DOM), provide precise visualization for accurate material placement, while the micro apical placement system ensures void-free MTA delivery.
View Article and Find Full Text PDFJ Clin Orthop Trauma
November 2025
Department of Orthopaedics, All India Institute of Medical Sciences, Bhubaneshwar, 751019, India.
Severe rigid scoliosis presents formidable surgical challenges, even for the most seasoned spine surgeons. Patients with idiopathic scoliosis frequently exhibit severe manifestations after years of progressive deformity, characterised by pronounced curves, significant rib humps, shoulder and trunk asymmetry, and cardiorespiratory complications associated with untreated scoliosis. In our practice, around one-third of patients with scoliosis present with advanced, severe, rigid scoliosis (>90° and 25 % correction on bending radiographs).
View Article and Find Full Text PDFEur Heart J Case Rep
September 2025
Department of Cardiology and Medical Intensive Care, Kepler University Hospital, Medical Faculty, Johannes Kepler University, Klinik für Innere Medizin 1, Med Campus III, Krankenhausstrasse 9 Linz 4021, Austria.
Background: Pericardial tamponade during pregnancy is rare. Diagnosis of pericardial effusion can easily be made by echocardiography. Thorough clinical assessment, laboratory testing and advanced cardiac imaging are necessary to identify the underlying cause of pericardial effusion and rule out other causes of chest pain.
View Article and Find Full Text PDFNat Commun
September 2025
Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
Stereocilia are F-actin-based cylindrical protrusions on the apical surface of inner ear hair cells that function as biological mechanosensors of sound and acceleration. During stereocilia development, specific unconventional myosins transport proteins and phospholipids as cargo and mediate elongation, differentiation and acquisition of the mechanoelectrical transduction (MET). How unconventional myosins localize themselves and cargo in stereocilia using energy from ATP hydrolysis is only partially understood.
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