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The European Commission's ban on routine tail docking has prompted this retrospective observational study to evaluate the short-term effects of transitioning to a fully undocked system. Twenty-two farms were assessed during three subsequent phases: total tail docking (step 1), subgroups of undocked pigs (step 2), and fully undocked pigs (step 3). Farmers received training in long-tail management and independently implemented it on their own farms. However, straw provision as environmental enrichment was mandatory, at least supplied during periods of pigs' restlessness. Overall, going through step 2 appears to be successful. However, transitioning to step 3 worsened mortality ( = 0.010) and the feed conversion ratio ( = 0.015) in weaners. Compared to step 1, the cost of producing 1 kg of meat in step 3 was 33.9% greater during weaning and 7.4% during fattening. Tail lesion prevalence at slaughter was greater in step 3 (41%), followed by step 2 (10%) and step 1 (1%). The hypothetical labour required to optimize straw management compared to the adopted system, ensuring its continuous availability, was estimated as 35 min/100 piglets/weaning cycle (EUR 4.37) and 10.5 h/100 pigs/fattening cycle (EUR 109). Under the conditions of this study, transitioning to a fully undocked system was not successful. Mandating only the non-continuous use of straw has proven insufficient, and greater efforts must be systematically implemented.
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http://dx.doi.org/10.3390/ani15091250 | DOI Listing |
Thromb Res
September 2025
Departamento de Química and Institute for advanced research in chemical Science (IAdChem), Facultad de Ciencias, Módulo 13, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
Platelet integrin αIIbβ3 is the final common effector of arterial thrombosis: it switches from a low-affinity to a high-affinity state, binds fibrinogen, and initiates the outside-in signals that stabilize a growing clot. Calcium- and integrin-binding protein 1 (CIB1) emerged as the first endogenous partner of the αIIb cytoplasmic tail and is now recognized as a dual-role adaptor. At rest, Ca-free CIB1 tethers the inner membrane clasp and restrains premature integrin activation; after ligand engagement, Ca-bound CIB1 docks onto αIIb, recruits focal-adhesion kinase and amplifies Src-dependent cytoskeletal remodeling.
View Article and Find Full Text PDFMetab Brain Dis
September 2025
Department of Pharmacology, SVKM's Dr Bhanuben Nanavati College of Pharmacy, V.M. Road, Vile Parle (W), Mumbai, India.
This study aimed to evaluate the antidepressant potential of Nitazoxanide (NTZ), an antiprotozoal drug with known anti-inflammatory and neuroprotective properties, in a chronic unpredictable mild stress (CUMS)-induced mice model of depression. NTZ was administered at doses of 75, 150, and 300 mg/kg, and its effects were assessed through a series of behavioral tests, including the forced swim test, tail suspension test, actophotometer test, and social interaction test. NTZ treatment at 150 and 300 mg/kg significantly improved behavioral and biochemical outcomes, relieving depressive-like symptoms and restoring neurochemical balance.
View Article and Find Full Text PDFTop Magn Reson Imaging
October 2025
BIOSPACE LAB, Nesles-la-Vallée, France.
Aims: Cardiac tumors are aggressive and asymptomatic in early stages, causing late diagnosis and locoregional metastasis. Currently, the standard of care uses gadolinium-based contrast agents for MRI, and the associated hypersensitivity reactions are a significant concern, such as gadolinium deposition disease. In addition, the proximity of cardiac lesions closer to vital structures complicates surgical interventions.
View Article and Find Full Text PDFFront Pharmacol
August 2025
College of Pharmacy, Binzhou Medical University, Binzhou, Shandong, China.
Introduction: Age-related macular degeneration (AMD) is a leading cause of vision loss in older adults, with limited effective treatments available. This study aimed to investigate the pharmacological effects of dihydromyricetin (DHM) on AMD and to identify its putative pharmacological targets through network analysis and molecular docking approaches.
Methods: experiments established an AMD model using sodium iodate (SI)-induced ARPE-19 cells, with CCK-8 assays determining 15 mM SI as the optimal modeling concentration and 100 μM DHM as the optimal treatment concentration.
Bioorg Chem
August 2025
Department of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Khyber Pakhtunkhwa, Pakistan. Electronic address:
This study explores the synthesis of new acyl hydrazide derivatives of mefenamic acid as potent analgesics with enhanced safety profiles. Thirteen compounds were synthesized via hydrazide intermediate functionalization and characterized spectroscopically (H/C NMR, and HRESI-MS). In vivo evaluation (acetic acid writhing, formalin paw licking, and tail immersion tests) revealed significant peripheral and central analgesic activity, with compounds 5 (N'-(4-chlorobenzoyl)) and 11 (N'-(2,4-dichlorophenyl)) outperforming mefenamic acid (81.
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