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http://dx.doi.org/10.1016/j.ccell.2025.04.012 | DOI Listing |
Adv Sci (Weinh)
August 2025
Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Obstetric antiphospholipid syndrome (OAPS) is an autoimmune disorder characterized by pathologic pregnancies and the presence of antiphospholipid antibodies (aPLs). Despite significant infiltration of decidual macrophages observed in OAPS patients, the underlying connections between decidual and peripheral immune cells remain unclear. In this study, an integrated single-cell atlas is constructed of the decidua and peripheral blood mononuclear cells (PBMCs) from OAPS patients and HCs.
View Article and Find Full Text PDFJ Integr Neurosci
July 2025
Department of Anesthesiology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, 225001 Yangzhou, Jiangsu, China.
Background: Thalamic hemorrhage pain (THP), a subtype of central post-stroke pain (CPSP), commonly develops following ischemic or hemorrhagic injury to the thalamus. Current therapeutic options remain inadequate due to the absence of well-defined molecular targets. This study aimed to elucidate critical genes implicated in THP pathogenesis through an integrated multi-omics approach.
View Article and Find Full Text PDFCirc Res
August 2025
Cardiovascular Section, Department of Medicine (T.V., M.T., M.N., K.F., L.M., K.E., S.W., S.S.), University of Oklahoma Health Science Center.
Background: We previously showed in a rat model of heart failure with preserved ejection fraction (HFpEF) that transcutaneous vagus nerve stimulation (tVNS) reduced cardiac fibrosis and inflammation. However, macrophage-mediated mechanisms through which tVNS rescues cardiac function remain poorly understood.
Methods: We induced HFpEF in 8-week-old mice by a combination of a high-fat diet and l-NG-nitro arginine methyl ester for 5 weeks, followed by 4 weeks of tVNS or sham stimulation.
J Nutr Biochem
July 2025
Department of Human Anatomy, Histology and Embryology, School of Basic Medical, Qingdao University, Qingdao, China. Electronic address:
Myocarditis refers to localized or diffuse inflammatory lesions of the myocardium. Experimental autoimmune myocarditis (EAM) in mice is commonly utilized as an animal model for studying the pathogenesis of myocarditis. Baicalein (BAI), the main active component extracted from Scutellaria baicalensis root, has been proven to possess diverse effects such as anti-inflammatory, anti-tumor, and antioxidant activities.
View Article and Find Full Text PDFAngiogenesis
June 2025
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Stroke is a leading cause of mortality and disability globally. Despite advancements in acute stroke therapies, patient outcomes with ischemic stroke remain suboptimal. Understanding its molecular mechanisms is crucial for developing effective treatments.
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