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Article Abstract
Herein, a nucleophilic substitution reaction between arylformic acids and α-bromo esters, facilitated by a CsCO-DMA system, is reported. This reaction occurs under mild conditions, yielding a diverse range of valuable lactic acid derivatives (34 examples) with good to excellent yields (up to 97%). Subtle factors, such as the ion-dipole interactions between CsCO, the substrates, and the solvent, may significantly influence the dynamics of the S2 reaction.
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| http://dx.doi.org/10.1002/open.202500129 | DOI Listing |
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Experiment Center, Jinan Key Laboratory of Traditional Chinese Medicine Preparation Research and Evaluation in Medical Institutions, Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Herein, a nucleophilic substitution reaction between arylformic acids and α-bromo esters, facilitated by a CsCO-DMA system, is reported. This reaction occurs under mild conditions, yielding a diverse range of valuable lactic acid derivatives (34 examples) with good to excellent yields (up to 97%). Subtle factors, such as the ion-dipole interactions between CsCO, the substrates, and the solvent, may significantly influence the dynamics of the S2 reaction.
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