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Article Abstract
Background: Chromosomal alterations serve as diagnostic and prognostic markers in acute leukemia. Given the evolving landscape of chromosomal abnormalities in acute leukemia, we previously studied these over two periods. In this study, we investigated the frequency of these abnormalities and clinical trends in acute leukemia in Korea across three time periods.
Methods: We retrospectively analyzed data from 1,787 patients with acute leukemia (319 children and 1,468 adults) diagnosed between 2006 and 2020. Conventional cytogenetics, FISH, and multiplex quantitative PCR were used for analysis. The patient groups were divided according to the following three study periods: 2006-2009 (I), 2010-2015 (II), and 2016-2020 (III).
Results: Chromosomal aberrations were detected in 92% of patients. The translocation was the most frequent. Over the 15-yr period, chromosomal aberrations showed minimal changes, with specific fusion transcripts being common among patients. ALL was more prevalent in children than in adults and correlated significantly with the and aberrations. The incidence of ALL increased during the three periods, with remaining common.
Conclusions: The frequency of chromosomal abnormalities in acute leukemia has changed subtly over time. Notably, the age of onset of adult AML has continuously increased. Our results may help in establishing diagnoses and clinical treatment strategies and developing various molecular diagnostic platforms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187495 | PMC |
| http://dx.doi.org/10.3343/alm.2024.0570 | DOI Listing |
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