98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065803 | PMC |
http://dx.doi.org/10.1038/s43856-025-00880-0 | DOI Listing |
J Phys Chem Lett
September 2025
Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal 462 066, Madhya Pradesh, India.
Reported herein are long-lived, red-luminescent silver nanoclusters (AgNCs) protected by the small-molecule ligand thiolactic acid, which exhibit exceptional stability (shelf life exceeding three years, photostability ∼100%), water-solubility, and high biocompatibility, making them suitable for diverse applications such as sensing and live-cell imaging. The AgNCs display extremely sensitive (>2% K) temperature-dependent luminescence, monitored by a dual approach of changes in photoluminescence intensity and excited-state lifetime, enabling precise local thermal environment monitoring with a very high-resolution temperature sensing down to subdegree levels (<0.5 K).
View Article and Find Full Text PDFComput Biol Med
September 2025
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; Institute of Molecular Biology and Biochemistry, The University of Lahore, Lahore, Pakistan; H.E.J. Research Institute of Chemistry
Estrogen receptor positive breast cancer (ERBC) is among the most common type of breast cancers. Currently aromatase inhibition is the mainstay therapy of ERBC. However, the emergence of drug resistance, and relapse of tumor progression has created the need of identification of new targets for drug development against ERBC.
View Article and Find Full Text PDFPLoS Pathog
August 2025
Department of Microbiology, Biocenter, University of Würzburg, Würzburg, Germany.
Staphylococcus aureus is a notorious human pathogen that thrives in macrophages. It resides in mature phagolysosomes, where a subset of the bacteria eventually begin to proliferate. How S.
View Article and Find Full Text PDFJ Mol Graph Model
November 2025
Department of Public Health, College of Applied Medical Sciences, Khamis Mushait Campus, King Khalid University (KKU), 62561 Abha, Saudi Arabia.
Neurodegenerative tauopathies, such as Alzheimer's disease, are closely associated with the dysregulation of tau phosphorylation, a process regulated in part by the serine/threonine kinase MARK4. In this study, we explored phytochemicals derived from Bacopa monnieri as potential natural inhibitors of MARK4. Using pressurized liquid extraction with an ethanol-water mixture, we efficiently extracted bioactive compounds from Bacopa leaves.
View Article and Find Full Text PDFCommun Med (Lond)
July 2025
Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, People's Republic of China.