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Quantum computing, based on quantum mechanics, has evolved due to the cross-pollination of concepts, methods, and strategies. The fusion of quantum computing with machine learning (ML) algorithms has shown satisfactory results in the case of low dimensionality spaces. However, in high dimensionality spaces, the computational complexity increases, thus leading to average accuracy and computation time. To combat this issue in this research work, a mathematical technique known as fuzzy logic (FL) has been integrated with quantum ML (QML) and applied to a medicine dataset of chronic disease. The fusion of two variables into one variable reduces the number of features hence transforming the high dimensional space into low dimensional space. ML implementation on the considered dataset has shown poor accuracy and took a large computation time. The integration of FL with ML (FML) has overcome this issue and optimized computation time and accuracy. Since QML shows poor accuracy and takes large computations when data sizes get larger as seen in different studies, therefore fuzzy concepts are integrated with QML, particularly with support vector machine (SVM) and K-nearest neighbor (KNN). Thus leading to the development of a hybrid model called FQML. The FQML has optimized the computation time and accuracy of the model as compared to QML. Moreover, all necessary features can be considered for the prediction of output which is very crucial, especially in medical diagnosis. Results of statistical analysis have also been performed between QML and FQML which has concluded that models are significantly different. Thus, a combination of FQML can overcome the QML computational complexity in high dimensional spaces by utilizing fuzzy logic concepts and can consider all necessary features required for better outcome prediction without compromising on computational complexity.
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http://dx.doi.org/10.1016/j.compbiomed.2025.110315 | DOI Listing |
Sud Med Ekspert
January 2025
Samara State Medical University, Samara, Russia.
Objective: To develop and implement a method for determining the postmortem interval and the marginal errors of its estimates under conditions of linearly varying external temperature in the format of an online application.
Material And Methods: A computer-assissted numerical search for the absolute minimum point of the objective function obtained from a system of nonlinear equations reflecting the results of double rectal or cranioencephalic thermometry of a corpse under conditions of linearly varying external temperature was carried out. The search algorithm was generalized to possible marginal errors in measuring the initial indicators of temperature and time.
J Phys Chem Lett
September 2025
Department of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, Oregon 97331, United States.
Carbon dots (CDs) represent a new class of nontoxic and sustainable nanomaterials with increasing applications. Among them, bright and large Stokes-shift CDs are highly desirable for display and imaging, yet the emission mechanisms remain unclear. We obtained structural signatures for the recently engineered green and red CDs by ground-state femtosecond stimulated Raman spectroscopy (FSRS), then synthesized orange CDs with similar size but much higher nitrogen dopants than red CDs.
View Article and Find Full Text PDFJAMA Cardiol
September 2025
Department of Cardiology, Inselspital University Hospital of Bern, University of Bern, Bern, Switzerland.
Importance: Right anomalous aortic origin of a coronary artery (R-AAOCA) is a rare congenital condition increasingly diagnosed with the growing use of cardiac imaging. Due to dynamic compression of the anomalous vessel, invasive fractional flow reserve (FFR) during a dobutamine-atropine volume challenge (FFR-dobutamine) is considered the reference standard. A reliable alternative method is needed to reduce extensive invasive testing, but it remains uncertain whether noninvasive imaging can accurately assess the hemodynamic relevance of R-AAOCA.
View Article and Find Full Text PDFMol Divers
September 2025
Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University, Nanjing, 211198, China.
Drug absorption significantly influences pharmacokinetics. Accurately predicting human oral bioavailability (HOB) is essential for optimizing drug candidates and improving clinical success rates. The traditional method based on experiment is a common way to obtain HOB, but the experimental method is time-consuming and costly.
View Article and Find Full Text PDFDrugs Aging
September 2025
Dalla Lana School of Public Health, University of Toronto, V1 06, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
Background And Objectives: Older adults living with dementia are a heterogeneous group, which can make studying optimal medication management challenging. Unsupervised machine learning is a group of computing methods that rely on unlabeled data-that is, where the algorithm itself is discovering patterns without the need for researchers to label the data with a known outcome. These methods may help us to better understand complex prescribing patterns in this population.
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