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Cognitive models of social anxiety disorder have conveyed the implication that self-focused attention (SFA) and post-event rumination (PER) are significant predictors in maintaining the symptoms of social anxiety (SA); however, their relationships have been scarcely studied in adolescents, including Chinese samples. The primary purpose of the current study was to examine the role of PER as a potential mediator between SFA and SA among Chinese adolescents; moreover, the moderation effect of gender was investigated. A total of 2,755 Chinese adolescents ranging in age from 11 to 19 years old with an average age of 14.18 were recruited from six urban public schools. Participants were asked to complete questionnaires measuring SFA, PER, SA, and depression. Structural equation modeling results showed that PER displayed as a plausible mediator in the relationship between SFA and SA, even after controlling for depression. In addition, gender was revealed to be a significant moderator, with a stronger relationship between PER and SA for girls than for boys. The current study provided evidence for Clark and Wells' proposition about the associations among SFA, PER, and SA, contributing to the field of adolescents' mental health and supporting the cultural applicability of the model.
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http://dx.doi.org/10.1080/13548506.2025.2502845 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Institut de Biologie de l'Ecole Normale Supérieure, Ecole Normale Supérieure, Université Paris Sciences et Lettres, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Paris 75005, France.
Excitatory glycine receptors (eGlyRs), composed of the glycine-binding NMDA receptor subunits GluN1 and GluN3A, have recently emerged as a novel neuronal signaling modality that challenges the traditional view of glycine as an inhibitory neurotransmitter. Unlike conventional GluN1/GluN2 NMDARs, the distribution and role of eGlyRs remain poorly understood. Here, we show that eGlyRs are highly enriched in the ventral hippocampus (VH) and confer distinct properties on this brain region.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Lübeck, Lübeck, Germany.
Importance: Patients with inflammatory rheumatic diseases (IRDs) frequently experience psychological distress; however, access to psychological support remains limited.
Objective: To investigate the effectiveness of a digital psychological intervention for individuals with IRDs.
Design, Setting, And Participants: Participants aged 18 years or older were recruited across Germany between February 22 and June 4, 2024, if they had been diagnosed with rheumatoid arthritis, psoriatic arthritis, or systemic lupus erythematosus and reported psychological distress and reduced quality of life.
Acta Neurol Belg
September 2025
Neuroscience Research Australia, University of New South Wales, Sydney, Australia.
Objectives: Patients diagnosed with amyotrophic lateral sclerosis (ALS) typically describe symptoms of fatigue. Despite this frequency, the underlying mechanisms of fatigue are poorly understood, and are likely multifactorial. To help clarify mechanisms, the present systematic review was undertaken to determine the risk factors related to fatigue in ALS.
View Article and Find Full Text PDFJ Neurol
September 2025
Multiple Sclerosis Center, Sheba Medical Center, Derech Sheba 2, Tel Hashomer, Israel.
Introduction: Psychological stress has been proposed as a trigger for disease activity in multiple sclerosis (MS), but findings have been inconsistent. While prior research has focused largely on chronic stressors, little is known about how people with MS (pwMS) cope with acute, large-scale stress events such as war.
Objective: Examine the effects of wartime stress following the October 7, 2023 attack on disease activity in pwMS, and to assess whether emotional factors are associated with relapse risk during this period.
Eur Arch Psychiatry Clin Neurosci
September 2025
School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Concerns over the mental health among young people have been increasing recently. We aimed to estimate the burdens of mental disorders, substance use disorders (SUDs), and self-harm at global, regional and national levels among adolescents and young adults aged 10-24 years from 1990 to 2021. Incidence, prevalence, and disability-adjusted life years (DALYs) of mental disorders, SUDs, and self-harm among young people were examined by age, sex, region, and country/territory.
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